Iimveliso

I-S-(+)-Methyl-(2-chlorophenyl)[(2-(2-thienyl)amino] i-acetate hydrochloride, ekwaziwa ngokuba yi-S-(+)-Clopidogrel, yikhompawundi yoxubo lwekhemikhali ye-C16H16ClNO2S·HCl. Yinto ephuma kwi-chiral ye-clopidogrel, eliyeza elibalulekileyo le-antiplatelet. isithako ekuqulunqweni kweziyobisi ze-cardiovascular, ngokukodwa i-antiplatelet agents.Isebenzisa iziphumo zayo zonyango ngokuthintela ukuhlanganiswa kweplatelet, ukuthintela ukubunjwa kwegazi, kunye nokunciphisa umngcipheko weziganeko ze-cardiovascular. Ngokuzibophelela ngokungenakuguquleka kule receptor, i-S-(+)-Methyl-(2-chlorophenyl)[(2-(2-thienyl)amino] iacetate hydrochloride inhibisa ukusebenza kweplatelet kwaye inqande ukwakheka. Amahlwili egazi Le ndlela yokwenza ikwenza ibe liyeza eliyimfuneko ekuthinteleni iziganeko zethrombotic kwizigulane ezisengozini enkulu, ezifana nezo zinembali ye-acute coronary syndrome, ischemic stroke, okanye peripheral artery disease.S-(+) -Methyl- (2-chlorophenyl) [(2-(2-thienyl) amino] i-acetate hydrochloride idla ngokuphathwa ngomlomo ngendlela yeepilisi okanye ii-capsules.Emva kokungeniswa, ifumana ukuguqulwa kwe-metabolic kwisibindi ukuvelisa i-metabolite yayo esebenzayo.Le metabolite esebenzayo ibophelela ngokungaguqukiyo kwi-P2Y12 receptor, isebenzise iziphumo zayo ze-antiplatelet ixesha elide.Ikhompawundi ngokuqhelekileyo imiselwe kanye yonke imihla, mhlawumbi njengonyango oluzimeleyo okanye ngokudibanisa namanye amayeza e-antiplatelet, afana ne-aspirin.Kubalulekile ukuqaphela ukuba i-S-(+) -Methyl-(2-chlorophenyl)[(2-(2) -thienyl)amino] i-acetate hydrochloride kufuneka isetyenziswe kuphela phantsi kwesikhokelo sokhathalelo lwempilo, njengoko ukusetyenziswa kwayo kunokuba namandla.