Iimveliso

(1R, 2S, 5S)—6,6-DiMethyl-3-aza-bicylo [3.1.0] i-hexane-2-carboxylic acid I-Methyl ester hydrochloride i-chemical compound kunye nezicelo ezahlukeneyo kuphando lwamachiza kunye nophuhliso lweziyobisi. usetyenziso oluphambili lwale khompawundi njengebhloko yokwakha i-chiral kwi-synthesis ye-pharmaceutical intermediates kunye nezithako ezisebenzayo zamachiza (APIs).Ubume bayo obukhethekileyo bebhayisikile kunye ne-chirality buyenza ixabiseke kwimveliso ye-enantiomerically pure compounds.Ngokubandakanya le ngqungquthela kwi-synthesis, i-chemist inokulawula i-stereochemistry kwaye idale iimpawu ezithile ze-pharmacological kwii-molecule ezibangelwayo.Oku kubaluleke kakhulu ekuphuhlisweni kweziyobisi, apho umsebenzi ofunekayo webhayoloji uhlala uxhomekeke kulungiselelo lwendawo yemolekyuli.Ukongeza, (1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane -2-carboxylic acid I-Methyl ester hydrochloride isetyenziswa njenge-precursor ye-synthesis yamachiza asekelwe kwi-quinuclidine.I-Quinuclidine derivatives ibonise uluhlu olubanzi lwemisebenzi ye-biological, kubandakanywa i-antipsychotic, i-anticonvulsant, kunye ne-analgesic properties.Ngokuzisa amaqela athile asebenzayo kwi-compound, i-chemist inokuguqula i-pharmacokinetic kunye ne-pharmacodynamic properties, ikhulise amandla ayo onyango.Ngaphezu koko, le ngqungquthela ifumana ukusetyenziswa njenge-reactant okanye i-catalyst kwiinguqu zezinto eziphilayo.Ngenxa yobukho be-amine ephakamileyo kunye nendalo ethintelwe ngokungqongqo yamaqela e-methyl, inokuthatha inxaxheba kwiindlela ezahlukeneyo zokusabela kweekhemikhali, ezinje nge-amidation, alkylation, kunye ne-cycloaddition reactions.I-reactivity yayo kunye nokukwazi ukwenza i-intermediates eyinkimbinkimbi yenza ukuba ibe sisixhobo esiguquguqukayo kwi-organic synthesis, evumela ukudalwa kwee-compounds ezihlukeneyo zesakhiwo. .0]i-hexane-2-carboxylic acid I-Methyl ester hydrochloride iyikhompawundi exabisekileyo ekuphuhliseni ichiza kunye ne-organic synthesis.I-chirality yayo kunye nesakhiwo esiyingqayizivele senza ukuba kuveliswe i-enantiomerically pure compounds kunye ne-synthesis yamachiza asekelwe kwi-quinuclidine kunye neempawu ezithile ze-pharmacological.I-reactivity yayo kwakhona iyenza i-reactant eluncedo kunye ne-catalyst kwiinguqu ezahlukeneyo zeekhemikhali.Ngokubanzi, le khompawundi idlala indima ebalulekileyo ekuqhubeleni phambili uphando lwamayeza kunye nophuhliso lweearhente ezintsha zonyango.