Iimveliso

(2-Chloro-5-iodophenyl) (4-fluorophenyl) i-methanone, eyaziwa ngokuba yi-CF12, yikhompawundi yemichiza enezicelo ezahlukeneyo kuphando lwamayeza kunye nokudibanisa. okanye ephakathi kwi-synthesis ye-organic compounds enzima ngakumbi.I-CF12 iqulethe amaqela asebenzayo afana ne-chloro kunye ne-fluoro substituents, enokuthi isetyenziswe ukwazisa amanye amaqela afunwayo okanye ukuguqulwa kwesakhiwo.Oku kuvumela oosokhemisti ukuba iipropati ikhompawundi kunye nokuphucula iimpawu zayo zekhemesti ukuba applications.CF12 ezithile ubonise amandla kuphuhliso abaviwa ichiza kuluhlu lwemimandla zonyango.Umzekelo, ubukho be-chloro kunye ne-fluoro substituents kwi-CF12 inokunyusa i-lipophilicity yekhompawundi, enokuthi ikhulise amandla ayo okungena kwiinwebu zebhayoloji kunye nokuphucula ukufunxwa kweziyobisi.Le propati inqweneleka ngokukodwa kuyilo lwamayeza alawulwa ngomlomo.Ukwengeza, iimpawu zesakhiwo zeCF12 zenza ukuba ngumviwa onomdla wokuhlola amandla ayo njenge-agent antimicrobial.Indibaniselwano yekhompawundi yeehalogen substituents ibonakaliswe ukubonisa umsebenzi obanzi wokulwa neentsholongwane ngokuchasene neentlobo ezahlukeneyo zebhaktiriya kunye nomngundo.Oku kuvula amathuba okuba iCF12 iphandwe kuphuhliso lwenoveli antibiotics okanye antifungal drug.Furthermore, CF12 kufunyaniswe ukuba izinto ezithile zebhayoloji ezenza umviwa ofanelekileyo kwezinye izicelo zonyango.Uphononongo lubonise ukuba i-CF12 ibonisa iimpawu ezichasene nokudumba, ezinokuthi ziyenze ixabiseke kunyango lwezifo eziphawulwa kukudumba, ezifana nokuphazamiseka kwe-autoimmune okanye izifo ezingapheliyo. uphando kunye nophuhliso luyafuneka ukuze uqonde ngokupheleleyo amandla alo njengomgqatswa weziyobisi.Uphononongo olubanzi lwe-preclinical, kubandakanywa uvavanyo lwe-vitro kunye ne-vivo, luyimfuneko ukuvavanya ukusebenza kwe-CF12, iipropati ze-pharmacokinetic, kunye neprofayili yokhuseleko.Ngaphezu koko, ukulungelelaniswa kwesakhiwo sekhemikhali yeCF12 kunye nokuphononongwa komsebenzi wayo ngokuchasene neenjongo zesifo ezithile ziyafuneka ukuze uvule amandla ayo onyango apheleleyo.Ngokufutshane, (2-Chloro-5-iodophenyl) (4-fluorophenyl) methanone (CF12) yikhompawundi ethi unesithembiso sophando lwamachiza kunye nokudibanisa.Ukuguquguquka kwayo njengebhloko yokwakha ivumela ukudala i-compound organic compounds, ngelixa iimpawu zayo ze-pharmacological ezifana ne-lipophilicity kunye nomsebenzi we-antimicrobial zenza ukuba ube ngumviwa onokuthi uphuhlise iziyobisi kwiindawo ezifana ne-antibiotics, i-antifungals, kunye ne-anti-inflammatory agents.Nangona kunjalo, uphando olubanzi lusafuneka ukuvavanya ngokupheleleyo amandla alo onyango kunye nokumisela ukusebenza kwalo njengomgqatswa wechiza.