Iimveliso

(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)imethanone, ekwaziwa ngokuba yiCF3-112, yikhompawundi yemichiza enezicelo ezininzi ezibalulekileyo kwicandelo lemichiza yamayeza kunye neziyobisi. uphuhliso.Enye yezinto eziphambili zokusetyenziswa kweCF3-112 njenge-kinase inhibitor.I-Kinase zii-enzymes ezilawula iinkqubo ezahlukeneyo zeseli emzimbeni, kubandakanya ukukhula kweeseli, ulwahlulo kunye nonxibelelwano.I-Dysregulation ye-kinases ihlala ihambelana nezifo ezinjengomhlaza kunye nokuphazamiseka kwe-autoimmune.I-CF3-112 ifunyenwe ibonisa umsebenzi onamandla wokuthintela ngokuchasene ne-kinases ethile, okwenza kube ngumviwa othembisayo wophuhliso lwezonyango ezijoliswe kuyo. badla ngokuchazwa kakhulu kwiiseli zomhlaza.Ngokujolisa ngokukhetha kunye nokuthintela ezi kinases, i-CF3-112 inokunceda ukumisa ukwanda ngokukhawuleza kweeseli zomhlaza kwaye inokuthi ibonelele ngenzuzo yonyango.Ngaphezu koko, i-CF3-112 ibonise umsebenzi ochasene nezinye i-kinases ezifana ne-FLT3 kunye ne-JAK2, ezichaphazelekayo kwi-hematological. izifo ezinobungozi ezifana ne-acute myeloid leukemia (AML) kunye ne-myeloproliferative neoplasms.Ukuthintela ezi kinases nge-CF3-112 inamandla okuphazamisa iindlela zokubonisa eziqhuba ukukhula kunye nokusinda kweeseli zomhlaza, ezinikezela ngamathuba amatsha okunyangwa kwezi zifo.Ukongezelela kumsebenzi wayo we-kinase inhibitory, i-CF3-112 inokuba nayo i-anti -iziphumo ezivuthayo.Ukuvuvukala kuyimpendulo enzima yebhayoloji edlala indima kwizifo ezininzi, kubandakanya ukuphazamiseka kwe-autoimmune kunye neemeko ezingapheliyo zokudumba.I-CF3-112 ibonise isithembiso njenge-inhibitor yeendlela ezithile zokuvuvukala, ezinokuthi zinikeze indlela yonyango yokulawula ezi meko.Nangona i-CF3-112 ibambe amandla amakhulu, kuyafaneleka ukuba kuqatshelwe ukuba uphando olongezelelweyo kunye nophuhliso luyafuneka ukuze kuqondwe ngokupheleleyo ukusebenza kwayo, ukhuseleko. iprofayili, kunye nesicelo esisiso.Njengayo nayiphi na i-compound, uvavanyo olungqongqo kunye nezifundo zangaphambili ziyafuneka ngaphambi kokuba ziqhubele phambili kwiimvavanyo zeklinikhi zabantu.Ekuqukumbeleni, i-CF3-112 yikhompawundi enobuchule obubalulekileyo kwintsimi ye-chemistry yamayeza.Umsebenzi wayo we-kinase inhibitory, ngokukodwa ngokuchasene ne-Aurora kinases, i-FLT3, kunye ne-JAK2, ibeka njengomviwa onokuthi uphuhlise unyango olujoliswe kuyo umhlaza kunye ne-hematological malignancies.Iipropathi zayo ezichasayo zikwacebisa izicelo ezinokubakho ekulawuleni ukuphazamiseka kwe-autoimmune kunye neemeko ezingapheliyo zokudumba.Nangona kunjalo, uphando olongezelelweyo luyimfuneko ukuvula amandla alo onyango olupheleleyo kunye nokuvavanya ukhuseleko kunye nokusebenza kwayo.