Iimveliso

I-2-Pyrrolidinecarboxamide, i-1- (2-chloroacetyl) -, (2S) - i-compound enezicelo ezahlukeneyo kwintsimi ye-organic chemistry kunye nophando lwamachiza.Le khompawundi, eyaziwa ngokuba (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide, ibonisa iimpawu zesakhiwo ezenza ukuba zilungele ukuphendulwa kweekhemikhali ezithile kunye nezifundo ze-biological.In organic synthesis, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic i-asidi i-amide ingasetyenziswa njengento yokuqala okanye ephakathi kwi-synthesis yeemolekyuli ezinzima ngakumbi.Ubume bayo be-chiral, kunye nobizo (2S), luthetha ukuba inolungelelwaniso oluthile lwe-dimensional-dimensional yee-athom ezinokuphembelela i-stereochemistry kunye neempawu zezinto eziphuma kuyo.Le propati yenza ukuba ixabiseke ekuyilweni nasekuveliseni amachiza amatsha kunye ne-pharmaceutical compounds.Kwishishini lamachiza, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide ifundwe ngamandla ayo njenge-inhibitor ye-enzymes okanye iiprotheni ezibandakanyekayo. iinkqubo ezithile zebhayoloji.Olunye uphando lugxininise kwisicelo salo njenge-inhibitor ye-proteases ethile, eyi-enzymes edlala indima kwiinkqubo ezahlukeneyo ze-physiological.Ngokujoliswa okukhethiweyo kunye nokuthintela ezi proteases, iziphumo ezifanelekileyo zonyango zinokufezekiswa.Ukongeza, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide inokusebenza njenge-precursor ye-synthesis ye-peptide analogs okanye i-mimetics.Ezi molekyuli zinokulinganisa ubume kunye nomsebenzi weepeptides ezenzeka ngokwendalo, ngaloo ndlela zibe nefuthe kwiithagethi ezithile zebhayoloji okanye imisebenzi.Ezo analogu zinokuba nezicelo ezinokuthi zibekho kuphuhliso lwamachiza okunyanga izifo ezahlukahlukeneyo, kuquka umhlaza, ukuphazamiseka kwemetabolism, kunye neemeko zemithambo-luvo.Kubalulekile ukuqaphela ukuba (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide isetyenziswa ikakhulu. kuphando lwebhubhoratri kwaye ayivunywanga ukusetyenziswa kweklinikhi.Izicelo zonyango ezinokuthi zisahlolisiswa, kwaye uphando olongezelelweyo luyafuneka ukuze kuqinisekiswe ukhuseleko lwalo kunye nokusebenza kakuhle ebantwini.Ekuqukumbeleni, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide iyikhompawundi enezicelo ezahlukeneyo kwi-organic synthesis kunye uphando lwamayeza.Ubume bayo be-chiral kunye namandla okuthintela i-enzymes okanye iiprotheni ezithile zenza ukuba zixabiseke kuphuhliso lwamachiza amatsha kunye nezicwangciso zonyango.Nangona ukusetyenziswa kwayo kuphando lwebhubhoratri kubonisa isithembiso, uphando olongezelelweyo luyimfuneko ukuze uqonde ngokupheleleyo amandla alo kwizicelo zeklinikhi.