Iimveliso

I-2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone, eyaziwa ngokuba yi-TMS-D-glucose, i-compound eguquguqukayo efumana izicelo kwiinkalo ezahlukeneyo zesayensi, kuquka i-organic synthesis, i-carbohydrate chemistry, kunye ne-analytical chemistry. I-TMS-D-glucose ibaluleke kakhulu kwi-organic synthesis njengoko isebenza njengeqela elikhuselayo kumaqela asebenzayo e-hydroxyl (OH) kwi-carbohydrates.Ngokuzisa amaqela e-trimethylsilyl (TMS) kumaqela e-hydroxyl ye-glucose, i-compound iyazinza kwaye ingasebenzi, ivumela ukuguqulwa okukhethiweyo kwamaqela athile e-hydroxyl ngelixa ishiya abanye bengachaphazeleki ngexesha lokuguqulwa kweekhemikhali ezilandelayo.Esi sicwangciso sokukhusela-sokukhusela sisetyenziswa ngokubanzi kwi-carbohydrate chemistry ukufezekisa i-regioselectivity efunwayo kunye ne-stereochemistry kwi-synthesis ye-carbohydrates eyinkimbinkimbi, i-glycoconjugates, kunye nemveliso yendalo.Kwi-chemistry yohlalutyo, i-TMS-D-glucose isetyenziswe njenge-reagent derivatization yokufumanisa kunye nokulinganisa. yeecarbohydrates.Ngokuguqula i-carbohydrates kwi-trimethylsilyl derivatives, i-volatility yabo kunye nokuzinza kwe-thermal kuphucula, okwenza kube lula ukuhlalutya nge-chromatography yegesi (GC) kunye ne-mass spectrometry (MS).Ubuchwephesha be-derivatization buphucula ubuntununtunu bokubona, buphucula ukusebenza kakuhle kokuhlukana, kwaye kwenza ukuba kuchongwe i-carbohydrates eyahlukeneyo kwimixube eyinkimbinkimbi, njengeesampuli zebhayoloji okanye iimveliso zokutya.I-TMS-D-glucose iphinda ifumane izicelo kwi-synthesis ye-reagents ezikhethekileyo kunye neeprobes zekhemikhali.I-reactivity yayo ekhethekileyo kunye nokuzinza kwenza kube yinto ebalulekileyo yokuqala yokulungiswa kwamanye ama-carbohydrate-derived compounds.Abaphandi banokuguqula i-trimethylsilyl moiety okanye batshintshe i-glucose moiety ukuze benze iikhompawundi ezineempawu ezithile, ezifana ne-fluorescent probes, i-enzyme inhibitors, okanye abaviwa beziyobisi.Ezi ziphuma zingaqeshwa kwizifundo ezahlukeneyo ze-biological kunye ne-biomedical, kubandakanywa ukucinga, ukuphuhliswa kweziyobisi, okanye ukuqonda i-carbohydrate-protein interactions.Nangona kunjalo, kubalulekile ukuqwalasela ukuba i-TMS-D-glucose, njengayo nayiphi na enye i-chemical compound, idinga ukuphathwa ngokufanelekileyo kunye nokhuseleko. ukulumkela.Abaphandi kufuneka baqinisekise ukungena komoya okwaneleyo kwaye basebenzise izixhobo ezifanelekileyo zokuzikhusela xa besebenza nale khompawundi ukunqanda iingozi zempilo ezinokubakho.Ukongezelela, njengayo nayiphi na i-reagent yeekhemikhali, ukucoceka, kunye nomgangatho we-TMS-D-glucose ibalulekile ekufumaneni iziphumo ezinokwethenjelwa kunye nokuzala kwakhona.Ukukwazi ukukhusela ngokukhethiweyo amaqela e-hydroxyl kwi-carbohydrates, ukusetyenziswa kwayo kuhlalutyo lwe-carbohydrate, kunye nokusetyenziswa kwayo ekudibaneni kwee-reagents ezikhethekileyo kuyenza ibe sisixhobo esibalulekileyo kwiinkalo ezahlukeneyo zenzululwazi.Ngokusebenzisa i-TMS-D-glucose, abaphandi banokuqhubela phambili izifundo zabo kwi-carbohydrate chemistry, i-glycoscience, kunye nemimandla ehambelana nayo, igalelo ekuphuhlisweni kweekhompawundi ezintsha, ukuxilongwa, kunye nee-arhente zonyango.