Iimveliso

Ikhompawundi (2S, 3R, 4R, 5S, 6R) -2- [4-Chloro-3- (4-ethoxybenzyl) phenyl] -6- (hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol yi. i-molecule ye-organic enzima kunye nezicelo ezibalulekileyo ezinokuthi zibekho kwiinkalo zekhemistri kunye ne-pharmacology.Onye usetyenziso olunokwenzeka lwale khompawundi kwintsimi ye-chemistry yamayeza.Ubukho bekloro, i-ethoxybenzyl, kunye namaqela e-hydroxymethyl bunika ithuba lokuphonononga unxibelelwano lwekhompawundi kunye neethagethi zebhayoloji kunye nokuvavanya amandla ayo njengearhente yonyango.Ulwakhiwo lwekhompawundi lucebisa ukuba lunokuba nomsebenzi wekhemesti okanye umboniso onokwenzeka wokufunyanwa kwechiza.Abaphandi banokuqhuba izifundo ezahlukeneyo, kubandakanya i-vitro kunye novavanyo lwe-vivo, ukuvavanya umsebenzi webhayoloji wekhompawundi, indlela yokusebenza, kunye namandla onyango.I-stereochemistry yekhompawundi eyodwa, kunye nendibaniselwano ye-S kunye no-R, inokuba negalelo kumsebenzi wayo webhayoloji, iyenze ibe yimolekyuli enomdla yophando oluqhubekayo.Abaphandi banokusebenzisa le khompawundi njengesixhobo sokuqala sokwenziwa kweemolekyuli ezintsonkothileyo okanye izinto eziphuma kwimveliso yendalo.Ngokwenza uhlengahlengiso olukhethiweyo kumaqela asebenzayo emolekyuli, iikhemisti zinokufumana iikhompawundi ezineempawu ezifunwayo, ezifana nokuphuculwa kobuchule bomayeza, ukunyibilika okuphuculweyo, okanye ukuncitshiswa kobuthi.Ubukho beqela le-hydroxymethyl luvula amathuba okuphucula ngakumbi, njengokuguqula ibe ngamaqela ahlukeneyo asebenzayo, okuvumela ukulungiswa kwelayibrari ehlukeneyo yeekhompawundi zokusetyenziswa kwezicelo ezahlukeneyo.Ngaphezu koko, amandla e-compound njengebhloko yokwakha i-chiral kwi-asymmetric synthesis. mayingahoywa.Ubukho bamaziko amaninzi e-chiral kwi-molecule ivumela ukulungiswa kweekhompawundi ezicocekileyo ze-enantiomerically, ezibalulekileyo kumashishini amayeza.Iikhemisti ze-Organic zinokuphonononga usetyenziso lwekhompawundi ekwakheni iimolekyuli ze-chiral ezintsonkothileyo, ezinokukhokelela ekufumaneni amachiza amatsha okanye uphuhliso lwenoveli yeendlela zokwenziwa.Kubalulekile ukuqaphela ukuba ukusebenza ngale khompawundi kufuna ubuchule bokuphatha kunye nokudibanisa iimolekyuli ze-organic ezintsonkothileyo.Abaphandi kufuneka baqaphele kwaye balandele iiprothokholi ezifanelekileyo zokhuseleko kuyo yonke inkqubo, ukusuka kwi-synthesis ukuya kwimpawu kunye nokusingatha. phenyl] -6- (hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol ibonisa amandla abalulekileyo kwi-chemistry yamayeza, i-synthetic organic chemistry, kunye ne-asymmetric synthesis.Ubume bayo obukhethekileyo kunye ne-stereochemistry ivula iindlela zokuqonda umsebenzi wayo webhayoloji, ukuyila iiarhente ezintsha zonyango, kunye nokuphuhlisa amaqhinga okwenziwa ekudaleni iimolekyuli zendalo ezintsonkothileyo.Uphononongo oluqhubekayo lweempawu zale khompawundi kunye nokusetyenziswa kwayo kunokuba negalelo kwinkqubela phambili yophuhliso lwamachiza, ukuhlanganiswa kweekhemikhali, kunye nokuqonda iinkqubo zebhayoloji.