![3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas:54827-17-7 99% Umfanekiso okhoyo](http://cdn.globalso.com/xdbiochems/54827-17-71.jpg)
3,3′,5,5′-Tetramethyl-[1,1'-biphenyl]-4,4′-diamine Cas: 54827-17-7 99%
| Inombolo Yekhathalogu | XD90518 |
| Igama lemveliso | 3,3',5,5'-Tetramethyl-[1,1'-biphenyl]-4,4'-diamine |
| CAS | 54827-17-7 |
| Ifomula yeemolekyuli | I-C16H20N2 |
| Ubunzima beMolekyuli | 240.34 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29215990 |
Ukucaciswa kweMveliso
| Imbonakalo | Mhlophe, ukusuka mhlophe ukuya ngwevu okanye umgubo omthubi |
| Isivavanyi | >99% |
| Ilahleko ekomisweni | <2.0% |
| Isetyenziselwa uphando kuphela, hayi ukusetyenziswa komntu | uphando lusetyenziselwa kuphela, kungekhona ukusetyenziswa komntu |
Ityhefu yeRicin (RT) yeyesibini eyona tyhefu iyingozi eyaziwayo;iye yonyulwa yi-CDC njenge-arhente ekhethiweyo.I-RT yenziwa sisityalo sembotyi ye-castor;kuqikelelwa ukuba iitoni ezingama-50,000 ze-RT ziveliswa ngonyaka njengemveliso yeoli ye-castor.I-RT ineeyunithi ezimbini, i-ribotoxic A chain (RTA) kunye ne-galactose-binding B chain (RTB).I-RT ibophelela kuzo zonke iiseli ze-mammalian kwaye xa sele ifakwe ngaphakathi, i-RTA enye yenza i-catalytically ingasebenzi zonke ii-ribosomes kwiseli.Ilawulwa njenge-aerosol, i-RT ibangela umonakalo okhawulezayo wemiphunga kunye ne-fibrosis elandelwa kukufa.Akukho zitofu ezivunyiweyo zoKutya kunye noLawulo lweziyobisi kwaye unyango lusebenza kuphela kwiiyure ezimbalwa zokuqala emva kokuba sesichengeni.Siye saphuhlisa isitofu sokugonya esiphinda sitshatyalaliswe se-RTA esinotshintsho olubini lwe-V76M/Y80A (RiVax).Iprotheyini ibonakaliswa kwi-Escherichia coli kwaye ayinayo ityhefu kunye ne-immunogenic kwiimpuku, imivundla kunye nabantu.Xa iimpuku ezigonyiweyo ziphonswa umngeni nge-RT etofwayo, i-aerosolized, okanye elawulwa ngomlomo (gavaged), zikhuselwe ngokupheleleyo.Ngoku siye saphuhlisa i-thermostable, i-aluminium-adjuvant-containing formulation ye-RiVax kwaye yavavanya kwi-rhesus macaques.Emva kokutofwa kathathu, izilwanyana zavelisa izilwa-buhlungu ezizikhusele ngokupheleleyo kwidosi ebulalayo ye-RT.Ezi zithinteli-mzimba ziye zathatha inxaxheba kwi-RT kwaye zakhuphisana ngokwemigangatho eyahluka-hlukeneyo ngephaneli yokungathathi hlangothi kunye ne-nonneutralizing mouse monoclonal antibodies ezaziwa ngokuqaphela iiepitopes ezithile kwi-RTA yasekhaya.Iprofayili yesiphumo sokhuphiswano lwe-antibody inokumela utyikityo lwe-immunologic yokhuseleko.Okubalulekileyo, utyikityo olufanayo lwabonwa kusetyenziswa isera evela kubantu abagonywe yiRiVax.
