Iimveliso

Ukuphanda umphumo weoli ye-spearmint kwiinguqu ezifana ne-emphysema kunye nokubonakaliswa kwe-tumor necrosis factor-alpha (TNF-alpha), i-interleukin-1beta (IL-1beta), i-matrix metalloproteinase-9 (MMP-9) kunye ne-tissue inhibitor ye-metalloproteinase. -1 (TIMP-9) kwi-lipopolysaccharide (LPS) ephathwayo iigundane.Imodeli yokutshintsha kwe-Emphysematous yenziwe nge-intracheal instillation ye-LPS kanye ngeveki ukuya kwiiveki ze-8 kwiigundane.Iigundane zahlulwe kulawulo, i-dexamethasone (0.3 mg x kg (-1)), kunye neoli ye-spearmint (10, 30,100 mg x kg (-1)) amaqela.Iqela ngalinye liphathwe nge-saline, i-dexamethasone, kunye ne-spearmint yeoli ngokulandelanayo kwiiveki ze-4.Emva koko ukubalwa kweeseli ezimhlophe zegazi ezipheleleyo kunye nokwahlukileyo kwi-bronchoalveolar lavage fluid (BALF) zaqhutywa.Utshintsho lwe-pathologic yezicubu zemiphunga ezifana nesakhiwo se-alveolar, ukuvutha komoya, kunye ne-goblet cell metaplasia zabonwa ngu-HE kunye ne-AB-PAS staining.Ukubonakaliswa kwe-TNF-alpha, i-IL-1beta, i-TIMP-1 kunye ne-MMP-9 yalinganiswa.Zombini i-spearmint kunye ne-dexamethasone yanciphisa ukutshatyalaliswa kwe-pulmonary alveolus.Inani elipheleleyo kunye nelohlukileyo leeseli ezimhlophe zegazi kwi-BALF kuquka i-neutrophile kunye ne-lymphocyte yeoli ye-spearmint 100 mg x kg (-1) kunye neqela le-dexamethasone lancitshiswa kakhulu, kwaye i-goblet cell metaplasia nayo yavinjelwa.I-Dexamethasone yayinempembelelo yokuthintela kwintetho ye-TNF-alpha, IL-1beta, TIMP-1 kunye ne-MMP-9.Ioli ye-Spearmint 30, i-100 mg x kg (-1) iyancipha kakhulu i-TNF-alpha kunye ne-IL-1beta ngokulandelanayo.Ioli ye-Spearmint 10, i-30 kunye ne-100 mg x kg (-1) yayingenayo impembelelo kwintetho ye-TIMP-1, kodwa inokunciphisa ukubonakaliswa kwe-MMP-9 ngokuphawulekayo kwizicubu zemiphunga. kuba iphucula ukutshatyalaliswa kwe-alveolar, ukudumba kwemiphunga, kunye ne-goblet cell metaplasia.Umatshini unokubandakanya ukunciphisa umxholo we-TNF-alpha, i-IL-1beta kunye nokuthintela ukugqithisa kwe-matrix metalloproteinase-9 kwizicubu zemiphunga.