Iimveliso

(3R, 4R) -1- (tert-Butoxycarbonyl) -4-methylpyrrolidine-3-carboxylic acid, eyaziwa ngokuba yi-Boc-4-methylproline, i-chemical compound esetyenziswa ngokubanzi kwintsimi ye-organic synthesis, ngokukodwa kwimveliso ye-organic synthesis. i-peptides kunye ne-peptidomimetics yezicelo ezahlukeneyo.Enye yezinto eziphambili zokusetyenziswa kwe-Boc-4-methylproline njengeqela elikhuselayo kwiqela le-amino le-amino acids ngexesha le-peptide synthesis.Amaqela akhuselayo lutshintsho lwexeshana olukhusela amaqela athile asebenzayo eemolekyuli ukukhusela ukusabela okungafunwayo ngexesha lenkqubo yokwenziwa.Kwi-peptide synthesis, i-Boc-4-methylproline iqeshwe njengeqela elikhuselayo leqela le-amine, livumela ukuba ukudibanisa okukhethiweyo kwamanye ama-amino acid enze ulandelelwano olufunwayo lwe-peptide.I-Boc-4-methylproline iphinda isebenze njengebhloko yokwakha i-chiral Ukuhlanganiswa kweekhompawundi ezahlukeneyo ezinemisebenzi yebhayoloji enokubakho.Njengomxube we-chiral, une-stereocenter, eyenza i-enantiomers ezimbini: (3R,4R) -Boc-4-methylproline kunye (3S,4S) -Boc-4-methylproline.I-enantiomer nganye inokubonisa iipropathi ezahlukeneyo ze-pharmacological kunye nonxibelelwano kunye neethagethi zebhayoloji.Ngokusebenzisa i-Boc-4-methylproline njengento yokuqala, i-chemist inokufikelela kuluhlu lwee-chiral compounds zokufumana iziyobisi kunye nophuhliso.Ngaphezu koko, i-Boc-4-methylproline derivatives ibonise imisebenzi ye-antimicrobial, antiviral, kunye ne-anticancer.Ezi khompawundi ziye zaphandwa amandla azo njengee-arhente zonyango ngokuchasene neentsholongwane ezahlukeneyo, kubandakanya ibhaktheriya, iintsholongwane, kunye neeseli zomhlaza.Ngokuguqula isakhiwo se-Boc-4-methylproline kunye nokuvavanya i-derivatives yayo, abaphandi banokuhlola amandla abo njengama-lead compounds okanye i-scaffold molecules yoyilo lwamachiza.Ngaphezu kwezicelo zayo kwi-peptide synthesis kunye nophuhliso lweziyobisi, i-Boc-4-methylproline nayo iyasebenza. ekudalweni kwe-peptidomimetics.I-Peptidomimetics ziikhompawundi ezilinganisa ubume kunye nomsebenzi weepeptides kodwa zibe nozinzo olongezelelweyo kunye neempawu ze-pharmacokinetic.I-Boc-4-methylproline ingasebenza njengebhloko yokwakha kwi-design kunye ne-synthesis ye-peptidomimetics, evumela ukuphuhliswa kwe-novel therapeutics kunye ne-bioavailability ephuculweyo kunye neenkcukacha ezijoliswe kuyo. Isishwankathelo, (3R,4R) -1-(tert-Butoxycarbonyl) - I-4-methylpyrrolidine-3-carboxylic acid, okanye i-Boc-4-methylproline, i-compound eguquguqukayo esetyenziswa ngokubanzi kwi-organic synthesis.Indima yayo njengeqela elikhuselayo kwi-peptide synthesis, kunye neempawu zayo ze-chiral, ziyenza ibe yibhloko yokwakha exabisekileyo ekudalweni kweepeptides, i-peptidomimetics, kunye ne-chiral compounds.I-derivatives ye-Boc-4-methylproline iphandwa ngemisebenzi yabo yebhayoloji enokubakho, equka i-antimicrobial, i-antiviral, kunye ne-anti-cancer properties.Uphando oluqhubekayo kunye nokutsha ekusebenziseni i-Boc-4-methylproline ekuyilweni kweziyobisi negalelo ekuphuhlisweni kwee-agent ezintsha zonyango kunye nokuphucula ukuqonda kwethu iinkqubo zebhayoloji ezinzima.