![(+)-(3r,5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5 -Dihydroxy-6 (E)-Heptenate (R1.5 Okanye T-Butyl-Rosuvastatin) CAS: 355806-00-7 Umfanekiso obonakalayo](http://cdn.globalso.com/xdbiochems/白色粉末1133.jpg)
![(+)-(3r,5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5 -Dihydroxy-6 (E)-Heptenate (R1.5 Okanye i-T-Butyl-Rosuvastatin) I-CAS: 355806-00-7](http://cdn.globalso.com/xdbiochems/粉末245.jpg)
(+)-(3r,5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5 -Dihydroxy-6 (E)-Heptenate (R1.5 Okanye i-T-Butyl-Rosuvastatin) I-CAS: 355806-00-7
| Inombolo Yekhathalogu | XD93420 |
| Igama lemveliso | (+)-(3r,5s), Tert-Butyl 7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methylsulphonylamino)-Pyrimidin-5-Yl]-3,5 -Dihydroxy-6(E)-Heptenate (R1.5 Okanye i-T-Butyl-Rosuvastatin) |
| CAS | 355806-00-7 |
| Ifomu yemolekyulila | I-C26H36FN3O6S |
| Ubunzima beMolekyuli | 537.64 |
| Iinkcukacha zokuGcina | I-Ambient |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe |
| uAsay | 99% imizuzu |
(+)-(3R,5S), tert-Butyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulphonylamino)-pyrimidin-5-yl]-3,5 -dihydroxy-6 (E) -heptenate, eyaziwa ngokuba yi-R1.5 okanye i-tert-butyl-rosuvastatin, i-chemical compound kunye nezicelo ezinokuthi zisetyenziswe kwi-pharmaceutical industry.I-Rosuvastatin yonyango eyaziwayo yokunciphisa i-cholesterol ephantsi kweklasi. amayeza abizwa ngokuba zii-statins.Isebenza ngokuthintela i-enzyme ebizwa ngokuba yi-HMG-CoA reductase, ebandakanyekayo ekuveliseni i-cholesterol emzimbeni.I-R1.5 i-derivative ye-rosuvastatin equkethe iqela le-tert-butyl elifakwe kwi-molecule, inika iipropati ezongezelelweyo kunye neenzuzo ezinokubakho.Esinye isicelo esinokwenzeka se-R1.5 njengesithako seyeza kunyango lwe-hyperlipidemia kunye nokuthintela izifo zentliziyo.Njenge-rosuvastatin, i-R1.5 ingasetyenziselwa ukunciphisa amanqanaba e-LDL cholesterol, eyaziwa nangokuthi "i-cholesterol embi", kunye ne-triglycerides egazini.Le khompawundi inokubonisa iipropati eziphuculweyo ze-pharmacokinetic, ezifana nokunyuka kwe-bioavailability okanye ukuzinza okuphuculweyo, xa kuthelekiswa neyeza elingumzali.Ngaphaya koko, iqela le-tert-butyl linokuba negalelo ekunyibilikeni kwekhompawundi kunye nokuqulunqwa kwezinto ezininzi, oko kuyenza ifaneleke kwiinkqubo ezahlukeneyo zokuhanjiswa kwamachiza.Olunye usetyenziso olunokubakho lwe-R1.5 kuphuhliso lwemveliso okanye iinkqubo ezichongiweyo zokuhanjiswa kwechiza.Iqela le-tert-butyl linokuthi lisebenze njengeqela elikhuselayo, livumela ukukhululwa okulawulwayo kwe-rosuvastatin kwizicubu ezithile okanye izitho, ezifana nesibindi.Esi sicwangciso-qhinga sinokuphucula ukusebenza kwechiza kunye nokunciphisa iziphumo ebezingalindelekanga ezinokubakhona ngokunyusa ukugxininiswa kwalo kwindawo ekujoliswe kuyo ngelixa kuncitshiswa ukuchanabeka kwizihlunu ezingajoliswanga. Ukongeza, i-R1.5 inokusebenza njengesixhobo esixabisekileyo samachiza ochemisti ekufumaneni ichiza nophuhliso.Ulwakhiwo oluntsonkothileyo lwekhompawundi lubonelela ngeqonga lohlengahlengiso olongezelelweyo kunye nezinto eziphuma kuzo.Abaphandi banokusebenzisa i-R1.5 njengekhompawundi ekhokelela ekuphononongeni ubume bobudlelwane bomsebenzi kunye nokuphuhlisa ii-analog ezintsha ezinamandla aphuculweyo, ukukhetha, okanye iiprofayili eziphuculweyo zonyango.Uphononongo olunjalo lunokuba negalelo ekuphuhliseni inoveli kunye ne-statins esebenzayo ngakumbi okanye ezinye ii-agent zokunciphisa i-cholesterol. Ekugqibeleni, (+) - (3R, 5S), tert-Butyl 7-[4- (4-fluorophenyl) -6-isopropyl -2-(N-methyl-N-methylsulphonylamino)-pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenate (R1.5 okanye i-tert-butyl-rosuvastatin) ibambe isithembiso njengekhompawundi yoxubo mayeza unyango lwe-hyperlipidemia kunye nezifo zentliziyo.Ulwakhiwo lwayo olulodwa, oludityaniswe neqela le-tert-butyl, lunokubonelela ngeenzuzo ezifana ne-pharmacokinetics ephuculweyo, unikezelo lwamachiza ekujoliswe kuwo, kunye namathuba ophuhliso lwamachiza olongezelelweyo.Uphando olongezelelweyo nophuhliso luyafuneka ukuze kuphononongwe ngokupheleleyo amandla e-R1.5 kwicandelo loxubo-mayeza.
