Iimveliso

I-Acetoxy Empagliflozin, ekwaziwa njenge-empagliflozin acetate, luhlobo olulungisiweyo lwechiza le-antidiabetic empagliflozin.I-Empagliflozin yeyodidi lweziyobisi ezaziwa ngokuba yi-sodium-glucose co-transporter 2 (SGLT2) inhibitors, ezisetyenziselwa ikakhulu ukulawula uhlobo lwe-2 yesifo sikashukela.Ngokuthintela le proteni, i-empagliflozin ikhuthaza ukukhutshelwa kweglucose ngomchamo, nto leyo ekhokelela ekwehleni amanqanaba eglucose egazini kubantu abanesifo seswekile.I-Acetoxy Empagliflozin iphuma kwi-empagliflozin eguqulwe ngokongezwa kweqela le-acetoxy.Olu hlengahlengiso lujolise ekuphuculeni uzinzo kunye ne-bioavailability yechiza, enokuthi ikhokelele kwiziphumo zonyango eziphuculweyo.Usetyenziso oluphambili lwe-Acetoxy Empagliflozin luhlala lugxile kulawulo lohlobo lwe-2 yesifo seswekile.Xa ithathwa ngomlomo, yenza ngokunciphisa i-renal glucose reabsorption, okukhokelela ekunyuseni kwe-urinary glucose excretion.Le ndlela inceda ukunciphisa amanqanaba e-glucose yegazi kunye nokuphucula ukulawulwa kwe-glycemic kwizigulane ezinesifo sikashukela sohlobo lwe-2. Ukongeza kwimiphumo yayo yokunciphisa i-glucose, i-SGLT2 inhibitors efana ne-Acetoxy Empagliflozin iboniswe ukuba ineenzuzo zesibini.Oku kubandakanya ukuphuculwa okunokwenzeka kwiziphumo ze-cardiovascular, ezifana nokunciphisa umngcipheko wokufa kwentliziyo, ukungaphumeleli kwentliziyo, kunye nesifo sohlangothi.Zinokukhokelela ekunciphiseni umzimba, ukunciphisa amanqanaba oxinzelelo lwegazi, kunye nokunciphisa imfuno ye-insulin okanye amanye amayeza e-antidiabetic.Kubalulekile ukuqaphela ukuba i-Acetoxy Empagliflozin, njengezinye i-SGLT2 inhibitors, ayikhuthazwa kubantu abanesifo seswekile okanye abo banesifo seswekile. ketoacidosis.Ngokuqhelekileyo imiselwe kunye nohlengahlengiso lwendlela yokuphila, kubandakanywa ukutya kunye nokuzilolonga, ukwandisa ulawulo lweswekile. Njengalo naliphi na iyeza, i-Acetoxy Empagliflozin inokuba neziphumo ebezingalindelekanga, kubandakanywa usulelo lomgudu womchamo, usulelo lwe-genital mycotic (yeast), ukonyuka kokuchama, isiyezi, kunye ne-hypoglycemia. .Kubalulekile ukuba umntu ngamnye othatha eli yeza abeke iliso kumanqanaba eglucose yegazi kwaye axele naziphi na iziphumo ebezingalindelekanga kumnikezeli wezempilo.Isebenza njenge-SGLT2 inhibitor, inceda ukunciphisa amanqanaba e-glucose yegazi kwizigulane ezinesifo sikashukela sohlobo lwe-2 ngokunyusa ukukhutshwa kwe-glucose ye-urinary.Inokuthi ibonelele ngezibonelelo ezongezelelweyo, ezifana ne-cardiovascular and weight-related benefits.Nangona kunjalo, njengalo naliphi na iyeza, kubalulekile ukulandela isikhokelo sokhathalelo lwezempilo kwaye ubeke iliso ngokusondeleyo kuzo naziphi na iziphumo ebezingalindelekanga.