Iimveliso

(3S) -3- [4- [(5-Bromo-2-chlorophenyl) methyl]phenoxy]tetrahydrofuran yikhemikhali yekhemikhali yeklasi ye-tetrahydrofuran derivatives.Ngokuqhelekileyo isetyenziswe kwinkalo yophando lwamachiza kunye nophuhliso ngenxa yezinto ezinokubakho zonyango.Enye yezicelo eziphambili zale khompawundi ixhomekeke ekukwazi ukusebenzisana neentlobo ezahlukeneyo ze-biological receptors, i-enzymes, okanye iiprotheni emzimbeni womntu.Oku kusebenzisana kunokukhokelela ekuguqulweni kweendlela ezithile ze-biochemical, ezinokuthi zibangele iziphumo zonyango.Abaphandi basoloko bephonononga indima yekhompawundi njengomviwa weziyobisi onokubakho kwizifo ezahlukeneyo.Iimpawu zesakhiwo sekhompawundi, kubandakanya ubukho beringi ye-tetrahydrofuran kunye neqela lephenyl elithathelwe indawo, linegalelo kwiimpawu zalo ezizodwa ze-pharmacological.Iqela le-phenyl libonelela ngokusebenzisana kwe-hydrophobic, enokuthi ichaphazele ukunyibilika kwe-compound kunye nokubopha ukudibanisa kwiiprotheni ezijoliswe kuyo.Ukongeza, ubukho be-bromine kunye ne-athom zeklorini kwiringi ye-phenyl yongeza ukuguquguquka kwi-reactivity yekhemikhali yekhompawundi, enokuthi ivumele unxibelelwano oluthe kratya kunye neeathom zebhayoloji ekujoliswe kuzo.Ubudlelwane obubophelelayo kunye nokukhetha kwe (3S) -3-[4-[(5 5). -Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran kwi-receptors ezithile okanye i-enzymes inquma izicelo zayo zonyango ezinokubakho.Ngenxa yoko, abaphandi baphanda iziphumo zayo kwiithagethi ezahlukeneyo zeemolekyuli, ezifana nezamkeli ezibandakanyekayo ekudumbeni, umhlaza, okanye ukuphazamiseka kwenkqubo yemithambo-luvo.Iimvavanyo ezahlukeneyo zebhayoloji kunye neemodeli zezilwanyana zinokuqeshwa ukumisela indlela yokusebenza kwayo, ukufunxa, ukuhanjiswa, imetabolism, kunye nokukhupha.Le datha ibalulekile ekuvavanyeni i-pharmacokinetics yekhompawundi kunye nokuqonda indlela edibana ngayo nomzimba womntu. Nangona kunjalo, kubalulekile ukuqaphela ukuba (3S) -3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran isekwinqanaba lophando, kwaye izicelo zayo zonyango ezinokubakho zisaza kuphononongwa ngokupheleleyo.Izifundo ezibanzi, kubandakanywa nezilingo zeklinikhi ebantwini, ziya kuba yimfuneko ukumisela ukhuseleko kunye nokusebenza kakuhle ngaphambi kokuba kuthathelwe ingqalelo ukusetyenziswa konyango.Ekuqukumbeleni, (3S) -3- [4- [(5-Bromo-2-chlorophenyl)] methyl ]phenoxy]tetrahydrofuran ngoku isaphandwa ngezicelo zayo zonyango ezinokubakho kwicandelo lophando lwamayeza.Ubume balo beekhemikhali obukhethekileyo bunegalelo ekusebenzisaneni okunokwenzeka kunye neethagethi ezithile zebhayoloji, okuvula amathuba okuphuhliswa kweearhente zonyango ezinoveli.Nangona kunjalo, uphando olongezelelweyo kunye novavanyo luyafuneka ukufumanisa amandla ayo okwenene njengekhompawundi yonyango.