![I-4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol CAS: 147118-36-3 Umfanekiso ofakiweyo](http://cdn.globalso.com/xdbiochems/白色粉末1130.jpg)
![4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol CAS: 147118-36-3](http://cdn.globalso.com/xdbiochems/粉末147.jpg)
4-(4-Fluorophenyl)-6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol CAS: 147118-36-3
| Inombolo Yekhathalogu | XD93412 |
| Igama lemveliso | 4-(4-Fluorophenyl) -6-isopropyl-2-[(N-methyl-n-methylsulfonyl)amino]pyrimidine-5-yl-methanol |
| CAS | 147118-36-3 |
| Ifomu yemolekyulila | I-C16H20FN3O3S |
| Ubunzima beMolekyuli | 353.41 |
| Iinkcukacha zokuGcina | I-Ambient |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe |
| uAsay | 99% imizuzu |
I-4-(4-Fluorophenyl) -6-isopropyl-2-[(N-methyl-N-methylsulfonyl) amino]pyrimidine-5-yl-methanol, eyaziwa ngokuba yi-Z6, i-chemical compound kunye nezicelo ezinokubakho kwintsimi yonyango. .Isakhiwo sayo esikhethekileyo kunye namaqela asebenzayo ayenza ibe ngumviwa onomdla wokufumana iziyobisi kunye nophuhliso.Onye ukusetyenziswa kwe-Z6 njenge-agent anti-inflammatory.Ukuvuvukala kudlala indima kwizifo ezininzi, kuquka i-rheumatoid arthritis, isifo sesibindi esivuthayo, kunye ne-asthma.Iqela le-phenyl le-fluoro-substituted ye-Z6 kunye ne-pyrimidine core yenza ukuba ilungele ukusebenzisana kunye neethagethi ezithile ezibandakanyekayo kwinkqubo yokuvuvukala, enokuthi iholele ekuphuhliseni inoveli yezidakamizwa ezichasayo.Usulelo lwentsholongwane luhlala luyinkxalabo yempilo yehlabathi jikelele, kwaye kukho imfuneko eqhubekayo yonyango olutsha nolusebenzayo lwe-antiviral.Ubukho beqela le-isopropyl kwi-Z6 kuphucula iimpawu zayo ze-hydrophobic, zivumela ukuba zikwazi ukungena kwi-membrane yentsholongwane kwaye zithintele ukuphindaphinda kwentsholongwane.Iimpawu zayo zesakhiwo zingaphuculwa ukuba zijolise ngokukodwa kwii-enzyme zentsholongwane okanye iiprotheni, ezikhokelela ekuphuhlisweni kweziyobisi ezinamandla ezilwa nentsholongwane.Iqela le-fluoro-substituted phenyl kunye ne-pyrimidine core zihlala zifumaneka kwiikhompawundi kunye nomsebenzi we-anticancer.Ngokuguqula ubume be-Z6, kunokwenzeka ukwenza izinto eziphuma kuzo ezijolise ngokukhethekileyo kwiiseli zomhlaza, zithintele ukukhula kwazo kwaye zibangele i-apoptosis ngelixa usindisa iiseli ezisempilweni.I-solubility ye-compound kunye nokuzinza kwayo kunokwandiswa ukuphucula ukusebenza kwayo kunye nokunciphisa iziphumo ezinokuthi zibe nemiphumo emibi.Ngaphezu koko, i-Z6 ingasetyenziselwa njengendawo yokuqala yokwenziwa kweelayibrari ezincinci ze-molecule okanye i-scaffolds yeekhemikhali.Inika ukuguquguquka kokuguqulwa kunye nokulungelelaniswa, ukuvumela ukuphononongwa kobudlelwane bomsebenzi wesakhiwo kunye nokuchongwa kweekhompawundi ezikhokelayo zophuhliso oluqhubekayo.Ngokufutshane, i-Z6 iyikhompawundi ethembisayo kunye nezicelo ezinokubakho kwintsimi yamachiza.Iimpawu zayo zesakhiwo kunye namaqela asebenzayo zenza ukuba zilungele iinjongo ezahlukeneyo zonyango, kubandakanywa ne-anti-inflammatory, antiviral, kunye ne-antiticancer applications.Ngophando olongezelelweyo kunye nophuhliso, i-Z6 kunye nezinto eziphuma kuyo ibambe amandla okwenza igalelo elibalulekileyo ekufumaneni amachiza kunye negalelo kuphuhliso lwenoveli kunye nonyango olusebenzayo.
