4-Amino-1-((2R,4S,5R) -4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-enye Cas:951-77-9
| Inombolo Yekhathalogu: | XD90580 |
| Cas: | 951-77-9 |
| Ifomula yeemolekyuli: | I-C9H13N3O4 |
| Ubunzima beMolekyuli: | 227.22 |
| Ubukho: | Ikhona evenkileni |
| Ixabiso: | |
| Ukupakisha kwangaphambili: | 1g USD10 |
| Ipakethe enkulu: | Cela iQuote |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe wekristale |
| Isivavanyi | 99% |
| Indawo yokunyibilika | 196°C - 200°C |
I-Thymidine phosphorylase (TP, EC 2.4.2.4) yaqaphela isakhiwo se-substrate kunye neenkcukacha eziphezulu, ngokusebenzisa zombini isiseko kunye ne-ribosyl moieties.Ukutshintshwa kwe-3'-OH ye-thymidine ichaphazele ngokuphawulekayo umsebenzi wayo we-catalytic nge-TP.Ukuguqulwa kwee-nucleosides ze-pyrimidine kunye ne-moieties yesiseko esilungisiweyo kwifom ehambelana ne-1-phosphate yayingalunganga.Umsebenzi weqela elishiyayo wehla ngokunyuka kwe-aromatics ye-pyrimidine base moiety, ngenxa yobunzima obuninzi bokwenza i-polarizing isiseko ngama-amino acids wendawo kwindawo esebenzayo.Ukutshintshwa kwe-3 'kunye ne-5' amaqela asebenzayo athande ukunciphisa izinga lokuphendula kunye nepesenti yokuguqulwa kwe-TP.Ngokukodwa iqela le-ribosyl 3' hydroxyl lalibalulekile ngokwesakhiwo ekubopheni i-substrate yi-enzyme.I-kinetic assay ibonise ngokucacileyo i-K (m) ephezulu kunye ne-V ephantsi (max) amaxabiso ekutshintsheni i-3' yeqela le-hydroxyl nge-hydrogen.
