Iimveliso

1. Injongo yolu phononongo yayikukuphuhlisa imodeli elula ye-pharmacokinetic-pharmacodynamic (PK-PD) enokuthi ibonakalise ixesha elipheleleyo leenguqu kwizibalo zeplatelet ukuqikelela ukuqala kunye neqondo le-thrombocytopenia, elinciphisa kakhulu ukusetyenziswa kwe-thrombocytopenia. i-agent ye-anticancer 5-fluorouracil (5-FU), kwiigundane.2. Izibalo zeplatelet zilinganiswe kwiigundane ezilandela ukulawulwa kwe-intravenous ye-dose eyahlukeneyo ye-5-FU kwiintsuku ze-4 ukufumana idatha yokuhlalutya imodeli ye-PK-PD.Imodeli yethu ye-PK-PD iqulethwe imodeli ye-PK yamacandelo amabini, kunye namacandelo amathathu emodeli ye-PD kunye ne-10 yeeparamitha ze-PK-PD zesakhiwo.3. Emva konyango lwe-5-FU, izibalo zeplatelet ziyancipha ngokukhawuleza ukuya kwinqanaba le-nadir, zibonise ukuphindaphinda ukuya ngaphaya kwenqanaba lesiseko ngaphambi kokubuyisela kumanqanaba asezantsi.Izibalo zeNadir platelet kunye ne-rebounds zahluka ngokwenqanaba le-AUC0-∞.Imodeli yokugqibela ye-PK-PD ibonakalise ngokufanelekileyo idatha yokubala iplatelet kunye neeparamitha zokugqibela zePD ziqikelelwe ngokuqiniseka okuphezulu.4. Lo mzekelo we-PK-PD kunye nokulinganisa kunokubonisa isixhobo esixabisekileyo sokulinganisa kunye nokuqikelela ixesha elipheleleyo lokuguqulwa kwenani leeseli zegazi, kwaye linokuba negalelo ekuphuhliseni izicwangciso zonyango kunye ne-5-FU kunye novavanyo lwee-agent ezahlukeneyo ze-anticancer. ekunzima ukuzihlola ebantwini.