I-5-Iodo-2′-deoxycytidine CAS: 54-42-2 98-102% I-crystalline powder emhlophe
| Inombolo Yekhathalogu | XD90562 |
| Igama lemveliso | 5-Iodo-2'-deoxycytidine |
| CAS | 54-42-2 |
| Ifomula yeemolekyuli | I-C9H11IN2O5 |
| Ubunzima beMolekyuli | 354.10 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29349990 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe wekristale |
| Isivavanyi | 99% |
| Ukujikeleza okuthe ngqo | +25 ukuya +30 |
| Iintsimbi ezinzima | <0.001% |
| Ilahleko ekomisweni | <1.0% |
| Intsalela kwi-Ignition | <0.3% |
Isakhiwo esiqikelelwayo se-3D se-DNA ephindwe kabini siyiguqulela ngokufanelekileyo njenge template yoyilo olusezantsi lweendawo ezisebenzayo ze-nucleic acid-based based active.Silapha siphonononga ukusetyenziswa kwe-14mer DNA duplex njenge-scaffold yokubeka ngokuchanekileyo kunye nokuqikelelwa kokuma kwemisebenzi ye-catalytic.Ukunikezelwa kokuthatha inxaxheba kwendawo yonke yeqela le-histidine-based imidazole ekuqaphelisweni kweprotheni kunye neziganeko ze-catalysis, i-duplexes enye ye-histidine-efana ne-modified duplexes yaphandwa.Ukubopha i-histamine kwi-C5 yesiseko se-thymine ngokusebenzisa ibhondi ye-amide, ivumela indawo eguquguqukayo yomsebenzi we-imidazole kwi-groove enkulu.Ukusebenzisana phakathi kwe-imidazole kunye ne-duplex kunye nefuthe layo kwi-imidazolium pKaH iphandwa ngokubeka i-thymine eyodwa eguquliweyo kwiindawo ezine ezahlukeneyo phakathi kwe-14mer double helix.Ukusebenzisa i-NMR kunye ne-dynamics ye-molecular dynamics, i-motif yesakhiwo ebandakanya ukubunjwa kwebhondi ye-hydrogen phakathi kwe-imidazole kunye ne-Hoogste kwicala leziseko ze-guanine zezibini ezimbini ze-GC ezingabamelwane ziyasekwa.I-motif inegalelo ekuzinzisweni kwe-thermal melting ye-6 ° C kwaye ingundoqo ekumodareyitheni i-pKaH yeqela le-imidazolium.Iimpawu eziqhelekileyo, izinto ezifunekayo kunye nophawu oluqhelekileyo lwemotif entsha yokulawula i-pKaH ichaziwe.
