5,5-Dithiobis (2-nitrobenzoic acid) Cas: 69-78-3 99% Ingca yomgubo omthubi
| Inombolo Yekhathalogu | XD90158 |
| Igama lemveliso | 5,5-Dithiobis(2-nitrobenzoic acid) |
| CAS | 69-78-3 |
| Ifomula yeemolekyuli | I-C14H8N2O8S2 |
| Ubunzima beMolekyuli | 396.35 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29309098 |
Ukucaciswa kweMveliso
| Inombolo Yekhathalogu | XD90158 |
| Igama lemveliso | 5,5-Dithiobis(2-nitrobenzoic acid) |
| CAS | 69-78-3 |
| Ifomula yeemolekyuli | I-C14H8N2O8S2 |
| Ubunzima beMolekyuli | 396.35 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29309098 |
Ukuqulunqwa kwe-Acyl-CoA kuqalisa i-cell fatty acid metabolism.I-Acyl-CoAs iveliswa yi-ligation ye-fatty acid kwi-Coenzyme A edibeneyo yintsapho enkulu ye-acyl-CoA synthetases (ACS).Ngakolunye uhlangothi, i-acyl-CoAs inokuthi ifakwe i-hydrolyzed yintsapho ye-acyl-CoA thioesterases (ACOT).Apha, sizimisele ukulawulwa kwe-transcriptional yazo zonke i-ACS kunye ne-ACOT enzymes kuzo zonke izicubu kunye nokuphendula ukuphazamiseka kwe-metabolic.Sifumana iipateni zolawulo olulungelelanisiweyo ngaphakathi naphakathi kwezi ntsapho zemfuza kunye nommiselo owahlukileyo owenzeka ngendlela exhomekeke kwithishu kunye neyomzimba.Ngenxa yoqwalaselo lotshintsho kwitsheyini ende ye-ACOT mRNA kunye nobuninzi beprotheyini kwisibindi kunye nezicubu ze-adipose, siye sagqiba isiphumo sokunyuka komsebenzi we-cytosolic long-chain thioesterase kwi-fatty acid metabolism kwezi zihlunu ngokwenza iimpuku ze-transgenic overexpressing i-hyperactive mutant ye-Acot7 isibindi okanye izicubu ze-adipose.Umsebenzi ophindwe kabini we-cytosolic acyl-CoA thioesterase awuphumelelanga ukukhusela i-mic e ekutyebeni okubangelwa kukutya, isibindi esinamafutha okanye ukunganyangeki kwe-insulin, nangona kunjalo, ukugqithiswa kwe-Acot7 kwi-adipocytes kwenza iimpuku zingakwazi ukunyamezela.Ngokudibeneyo, ezi datha zibonisa iindlela ezahlukeneyo zolawulo lwe-ACS kunye ne-ACOT enzymes kwaye ezi enzymes zisebenza ngendlela elungelelanisiweyo ukulawula i-fatty acid metabolism ngendlela exhomekeke kwizicubu.
