Iimveliso

I-5,6-Dihydro-3- (4-morpholinyl) -1-[4-(2-oxo-1-piperidinyl) phenyl] -2 (1H) -pyridinone, eyaziwa ngokuba yi-DMPHP, i-heterocyclic compound kunye nezicelo ezahlukeneyo. kwikhemikhali yamayeza kunye nokufunyanwa kweziyobisi.Nantsi inkcazo yokusetyenziswa kwayo malunga namagama angama-300. I-DMPHP iyaziwa ngokukwazi kwayo njengento enamandla kunye ne-inhibitor ekhethiweyo yee-enzymes ezithile kunye ne-receptors emzimbeni womntu.Enye yezicelo zayo eziphambili kwintsimi ye-kinase inhibition.I-Kinases zii-enzymes ezidlala indima ebalulekileyo kwiindlela zokubonisa iiseli kwaye zihlala zibandakanyeka kwizifo ezahlukeneyo, kubandakanya umhlaza.I-DMPHP ifunyenwe ngokunqanda ngokukhethekileyo i-kinases ethile, ngaloo ndlela iphazamisa i-cascade ye-aberrant signaling cascades enegalelo ekuqhubekeni kwesifo.Oku kwenza ukuba kube ngumviwa othembisayo wokuphuhliswa kweendlela zonyango ezijoliswe kuzo kwiintlobo zezifo, ezibandakanya umhlaza, ukuvuvukala, kunye nokuphazamiseka kwe-neurological disorders.Ngaphezu koko, i-DMPHP ibonise amandla kummandla wokulwa nokuvuvukala kunye ne-immunomodulatory.Ukukrala yimpendulo yendalo yomzimba kusulelo okanye ukwenzakala kodwa kunokuba yinto engapheliyo kwaye ikhokelele kwizifo ezahlukeneyo.I-DMPHP ibonise ukukwazi ukuthintela iindlela ezithile eziphazamisayo, ukunciphisa ukuveliswa kwabalamli abavuthayo.Le propati yenza kube sisixhobo esibalulekileyo ekuphuhliseni iziyobisi ezichasayo, ezincedisa unyango lweemeko ezifana ne-rheumatoid arthritis, isifo sofuba, kunye ne-asthma. .Ubuhlungu obungapheliyo ngumcimbi obalulekileyo wezempilo, kwaye iindlela zonyango zangoku zihlala zinemida okanye iziphumo ezingafunekiyo.I-DMPHP ibonise iziphumo ze-analgesic kwizifundo zangaphambili, iphakamisa amandla ayo njengenoveli yonyango yokulawula intlungu.Ngokumodareyitha i-receptors ethile kunye ne-neurotransmitters ebandakanyekayo kwintlungu yentlungu, i-DMPHP inokunika enye indlela yokulawula intlungu enokuthi ibe nemiphumo embalwa.Iimeko ze-neurological ezifana nesifo se-Alzheimer kunye nesifo sika-Parkinson zibandakanya iindlela eziyinkimbinkimbi kunye nokuphazamiseka kwee-receptors ezahlukeneyo kunye nee-enzymes kwingqondo.I-DMPHP iye yaphononongwa ngesakhono sayo njenge-agent ye-neuroprotective kunye namandla ayo okuphucula ukusebenza kwengqondo.Ngokujolisa i-receptors ethile kunye neendlela ezibandakanyekayo kwiingxaki ze-neurodeergenerative, i-DMPHP ibambe isithembiso njengongenelelo lonyango kule meko inzima. I-1-piperidinyl) phenyl] -2 (1H) -pyridinone (DMPHP) i-compound eguquguqukayo kunye nezicelo ezinokubakho kwi-kinase inhibition, umsebenzi wokulwa nokuvuvukala, i-analgesia, kunye ne-neuroprotection.Ikhono layo lokukhetha ukulungelelanisa ngokukhethekileyo i-enzymes kunye ne-receptors ezibandakanyekayo kwiindlela zesifo kwenza kube ngumgqatswa onomdla wokufumana iziyobisi kunye nokungenelela kwonyango.Uphando olongezelelweyo kunye nophuhliso lunokufumanisa ukusetyenziswa okongeziweyo kunye nokwandisa iipropathi zalo kwiimpawu ezithile.