Iimveliso

I-5,6,7,7a-Tetrahydrothieno [3,2-c] pyridine-2 (4H) -enye i-hydrochloride, eyaziwa ngokuba yi-riluzole hydrochloride, iyeza elisetyenziswa ngokukodwa kunyango lwe-amyotrophic lateral sclerosis (ALS), ekwabizwa ngokuba sisifo sikaLou Gehrig.Iyeza lomlomo elisebenza ngokumodareyitha amanqanaba e-glutamate, i-neurotransmitter ye-excitatory, kwingqondo.I-Riluzole hydrochloride icingelwa ukuba isebenze ngokunciphisa ukukhululwa kwe-glutamate, inhibiting glutamate uptake, kunye nokuvimbela i-glutamate receptors.I-Glutamate ikholelwa ukuba idlala indima ekuqhubeleni phambili kwe-ALS kwaye ngokumodareyitha amanqanaba ayo, i-riluzole hydrochloride inokunciphisa ukuchithwa kwe-motor neurons kwaye inokunceda ekwandiseni ubomi.Ngaphandle kokusetyenziswa kwayo kwi-ALS, i-riluzole hydrochloride nayo iphandiwe ngenxa yayo. Ukusetyenziswa okunokwenzeka kwezinye izifo ze-neurological ezifana nesifo se-Alzheimer, i-multiple sclerosis, kunye nokudakumba.Nangona kunjalo, ukusebenza kwayo kwezi meko kusafundwa kwaye uphando olongezelelweyo luyafuneka.Njengoko nawaphi na amayeza, i-riluzole hydrochloride inokubangela iziphumo ezibi.Iziphumo ebezingalindelekanga eziqhelekileyo ziquka isicaphucaphu, ukuhlanza, isiyezi, ubuthathaka, kunye neentlungu zesisu.Iziphumo ebezingalindelekanga ezingaxhaphakanga kakhulu kodwa ezibi kakhulu zinokubandakanya iingxaki zesibindi, ukuchasana nomzimba, kunye notshintsho kumanani egazi.Kubalulekile ukuxoxa ngayo nayiphi na ingozi enokubakho kunye neenzuzo kunye nochwepheshe bezempilo ngaphambi kokuba uqale i-riluzole hydrochloride.Ekuqukumbeleni, i-5,6,7,7a-Tetrahydrothieno[3,2-c]pyridine-2 (4H) -enye i-hydrochloride, okanye i-riluzole I-hydrochloride, liyeza elisetyenziselwa ukunyanga i-ALS ngokumodareyitha amanqanaba e-glutamate engqondweni.Ngelixa isebenza ngokucotha ukuqhubela phambili kwe-ALS, kunokubangela iziphumo ebezingalindelekanga ekufuneka zijongwe.Ukusetyenziswa kwayo kwezinye iimeko ze-neurological kusaphandwa.