I-Acriflavine, iCas engathathi hlangothi: 8048-52-0 I-Orenji ukuya ebomvu ukuya kumgubo obomvu-mdaka
| Inombolo Yekhathalogu | XD90521 |
| Igama lemveliso | I-Acriflavine, ingathathi hlangothi |
| CAS | 8048-52-0 |
| Ifomula yeemolekyuli | I-C14H14ClN3 |
| Ubunzima beMolekyuli | 259.73 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 38249993 |
Ukucaciswa kweMveliso
| Imbonakalo | Orenji ukuya kubomvu ukuya kumgubo obomvu-mdaka |
| Isivavanyi | 99% |
| AS | 10ppm ubukhulu |
| Ilahleko ekomisweni | 8% max |
| Amanzi anganyibilikiyo | 0.5% ubukhulu |
| Uthuthu olufakwe emanzini | 3.5% ubukhulu |
| Uvavanyo lwesiqulatho seklorine yomile @ 105 Deg C kangange 2hrs | 13.3 - 15.8% |
Uninzi lwamachiza omhlaza alukwazi ukuphelisa amathumba, nto leyo ekhokelela ekukhuleni kokunganyangeki ngamachiza kunye nokuphinda kwezifo.Ukubonakaliswa kweHedgehog kudlala indima ebalulekileyo ngexesha lophuhliso lwe-embryonic, kodwa ikwabandakanyeka kuphuhliso lomhlaza, ukuqhubela phambili, kunye ne-metastasis.I-Hedgehog receptor Patched (Ptc) yi-Hedgehog ebonisa i-gene ekujoliswe kuyo echazwe ngokugqithisileyo kwiiseli ezininzi zomhlaza.Apha, sibonisa ikhonkco phakathi kwe-Ptc kunye nokuchasana ne-chemotherapy, kunye nokubonelela ngengqiqo entsha kumsebenzi we-Ptc.I-Ptc icocwa kwi-plasma membrane xa idibene ne-ligand Hedgehog, okanye kunyango lweeseli ezine-Hedgehog ebonisa i-antagonist cyclopamine.Kuzo zombini ezi meko, emva kokufukanyelwa kweeseli nge-doxorubicin, i-agent ye-chemotherapeutic esetyenziselwa ulawulo lwezonyango lwemihlaza ephindaphindiweyo, siye sabona ukuthintela ukuphuma kwe-doxorubicin kwi-Hedgehog-responding fibroblasts, kunye nokwanda kokuqokelelwa kwe-doxorubicin kumhlaza emibini eyahlukeneyo. imigca yeseli eyaziwayo ngokubonakalisa amanqanaba e-aber rant ye-Hedgehog signaling components.Sisebenzisa inkqubo yokubonakalisa i-heterologous, sibonise ngokungqongqo ukuba ukubonakaliswa kwe-Ptc yomntu kunikeze ukuxhathisa ekuthinteleni ukukhula ngamachiza amaninzi apho i-chemotherapeutic agents ezifana ne-doxorubicin, methotrexate, temozolomide, kunye ne-5-fluorouracil.Ukuchasana ne-doxorubicin ehambelana nomsebenzi we-Ptc, njengoko kubonisiwe kusetyenziswa ukuguqulwa kwezigulane ze-Gorlin's syndrome apho i-Ptc-mediated effect kwi-Hedgehog signaling ilahlekile.Iziphumo zethu zibonisa ukuba i-Ptc ibandakanyeka kwi-efflux yamachiza kunye nokunganyangeki kwamachiza amaninzi, kwaye icebisa ukuba i-Ptc inegalelo kunyango lwe-chemotherapy kwiiseli zomhlaza.
