I-Fluorescein CAS: 2321-07-5 I-Orange ebomvu ye-crystalline powder
| Inombolo Yekhathalogu | XD90459 |
| Igama lemveliso | I-Fluorescein |
| CAS | 2321-07-5 |
| Ifomula yeemolekyuli | C20H12O5 |
| Ubunzima beMolekyuli | 332.31 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 32129000 |
Ukucaciswa kweMveliso
| Imbonakalo | I-Orenji / i-crystalline powder ebomvu |
| Isivavanyi | 99% |
| Ilahleko ekomisweni | 1% max |
Iprotheyini yeCerebral dopamine neurotrophic factor (CDNF) ibonakaliswe ukukhusela indlela ye-nigrostriatal dopaminergic xa inikwe njengokungeniswa kwe-intrastriatal kwimodeli yeempuku kunye nempuku yesifo sikaParkinson (PD).Kule sifundo, sivavanye umphumo we-neuroprotective we-CDNF ohanjiswe kunye ne-adeno-associated viral (AAV) serotype 2 vector kwi-rat 6-hydroxydopamine (6-OHDA) imodeli yePD.Iivektha ze-AAV2 ezifaka ikhowudi kwi-CDNF, i-glial cell line-derived neurotrophic factor (GDNF), okanye iprotein eluhlaza yefluorescent zaye zatofwa kwi-rat striatum.Uhlalutyo lwentetho yeprotheyini lubonise ukuba i-AAV2 ivector yethu yazisa ngokufanelekileyo i-neurotrophic factor genes kwingqondo kwaye yanika ukubonakaliswa okuhlala ixesha elide kweeprotheni.Kwiiveki ezimbini emva kwenaliti ye-AAV2 ye-vector, i-6-OHDA yatofwa kwi-rat striatum, idala ukuwohloka okuqhubekayo kwenkqubo ye-nigrostriatal dopaminergic.Unyango nge-AAV2-CDNF lubangele ukuhla okuphawulekayo kokujikeleza kwe-ipsilateral eyenziwe yi-amphetamine ngelixa ibonelela ngokukhusela inxalenye ye-tyrosine hydroxylase (TH) -i-immunoreactive cells kwi-rat substantia nigra pars compacta kunye ne-TH-reactive fibers kwi-striatum.Iziphumo ezivela kolu phononongo zibonelela ngobungqina obongezelelweyo bokuba i-CDNF inokuthathwa njengonyango olunokubakho lwesifo sikaParkinson.
