Adenosine 5'-monophosphate disodium ityuwa Cas: 4578-31-8
| Inombolo Yekhathalogu | XD90587 |
| Igama lemveliso | Adenosine 5'-monophosphate disodium ityuwa |
| CAS | 4578-31-8 |
| Ifomula yeemolekyuli | I-C10H12N5Na2O7P |
| Ubunzima beMolekyuli | 391.18 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29349990 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe okanye omhlophe |
| Isivavanyi | 99% |
| Iintsimbi ezinzima | <10ppm |
| Ubushushu boGcino | +20 °C |
| Umxholo wamanzi | <26.0% |
Ukubeka iliso kwi-pharmacodynamics ukongeza kwi-pharmacokinetics yenye yezicwangciso zokwenza ukuba unyango lwe-mycophenolate mofetil lube lomntu ngamnye.Injongo yolu phononongo yayikukuphuhlisa ulwelo olubuthathaka lwechromatography-tandem mass spectrometry (LC-MS/MS) iindlela zokuvavanya i-pharmacokinetics kunye ne-pharmacodynamics ye-mycophenolic acid (MPA).Ugxininiso lwe-mycophenolic acid glucuronide (MPAG), i-mycophenolic acid acyl-glucuronide, kunye ne-MPA engapheliyo kunye ne-MPAG, yagqitywa, kwaye umsebenzi we-inosine-5'-monophosphate dehydrogenase ubalwa ngokulinganisa ubuninzi bemveliso eveliswa xanthosine-5'-monophosphate (XMP). ) kunye ne-intracellular adenosine-5'-monophosphate emva kokufakwa kwe-peripheral blood mononuclear cell (PBMC) lysates.Ikholamu yeMastro (TM) engenazintsimbi kunye neepateni ezimbini zegradient zisetyenziselwe ukuphucula umda wobungakanani be-XMP ukuya kwi-0.1 μM.Kuluhlu loxinaniso lwe-MPA lweklinikhi, umgca wegophe lokulinganisa, ukuchaneka kwaphakathi kunye neentsuku zangaphakathi kunye nokuchaneka kwanelisa izikhokelo zoLawulo lokuTya kunye neziyobisi zase-US.Ugxininiso lwe-MPA kwi-hematopoietic stem cell transplant (HSCT) izigulane ezinqunywe yi-enzyme assay kunye nendlela ekhoyo ye-LC-MS / MS ibonise ukulungelelaniswa okulungileyo (r (2) = 0.95, p <0.001).Kolu phononongo, sixela iindlela ezinovelwano kunye neziqinisekisiweyo ze-LC-MS/MS zokuvavanya i-pharmacokinetics kunye ne-pharmacodynamics ye-MPA, evakalelwa ngokwaneleyo ukuvavanya ubungakanani obuncinci be-PBMC lysates eqokelelwe kungekudala emva kwe-HSCT.
