Iimveliso

I-histamine H4 receptor (HRH4), efunyenwe kuphela kwiminyaka eyi-13 eyadlulayo, ithathwa njengenjongo yechiza ethembisayo yokwaliwa, ukudumba, ukuphazamiseka kwe-autoimmune kunye nomhlaza, njengoko kubonakaliswa linani elikhula ngokuthe ngcembe lopapasho lwesayensi kunye nezicelo zelungelo elilodwa lomenzi wechiza.Nangona ubukho be-HRH4 bubonakaliswe kwi-testis, indawo yayo ethile okanye indima yayo ayikasekwa.Apha, sifuna ukuchonga ukubandakanyeka okunokwenzeka kwe-HRH4 kulawulo lwe-Leydig cell function.Siqale savavanya ukubonakaliswa kwayo kwiiseli ze-tumor ze-MA-10 ze-Leydig kwaye emva koko savavanya iziphumo zee-agonists ezimbini ze-HRH4 kwi-steroidogenesis kunye nokwanda.Sifumene ukuba i-HRH4 ibonakaliswe ngokusebenzayo kwiiseli ze-MA-10, kwaye ukusetyenziswa kwayo kukhokelela ekuvimbeleni i-LH / i-chorionic gonadotropin-induced cAMP imveliso ye-cAMP kunye ne-Star protein expression.Ngapha koko, siye sabona ukunciphisa ukwanda kweeseli emva kwe-24-h HRH4 unyango lwe-agonist.Siye safumanisa iindawo ze-HRH4 ezibonisa kuvavanyo oluqhelekileyo lwegundane, kwaye safumanisa i-HRH4 i-immunostaining kwiiseli ze-Leydig zeempuku ezineminyaka eyi-7-240 iintsuku, ngelixa iimpuku ezineentsuku ezingama-21 zikwabonisa i-HRH4 kwi-gametes yamadoda.Ekugqibeleni, siye savavanya isiphumo sokusebenza kwe-HRH4 kwi-proliferation ye-progenitor eqhelekileyo kunye ne-rat Leydig cell culture, kwaye zombini zibonakalise ukuba zichaphazeleka kwi-anti-proliferative effect ye-HRH4 agonists.Ukunikezelwa ngokubaluleka kwe-histamine (2-(1H-imidazol-4-yl) ethanamine) kumntu (patho) physiology, iinzame eziqhubekayo zijoliswe ekucaciseni iimpawu ezivelayo ze-HRH4 kunye ne-ligands yayo.Olu pho nonongo lubonisa iisayithi ezintsha ze-HRH4 inkcazo, kwaye kufuneka zithathelwe ingqalelo ekuyilweni kwe-HRH4 ekhethiweyo ye-agonists ngeenjongo zonyango.