I-Citicoline sodium Cas: 33818-15-4 CYTIDINE-5′-DIPHOSPHOCHOLINE
| Inombolo Yekhathalogu | XD90590 |
| Igama lemveliso | Citicoline sodium |
| CAS | 33818-15-4 |
| Ifomula yeemolekyuli | I-C14H25N4NaO11P2 |
| Ubunzima beMolekyuli | 510.31 |
| Iinkcukacha zokuGcina | -20°C |
| IKhowudi yoMrhumo eHarmonized | 29349990 |
Ukucaciswa kweMveliso
| Imbonakalo | Okumhlophe Okuqinileyo |
| Isivavanyi | 99% |
| Indawo yokunyibilika | 250°C(dec.)(lit.) |
| Indawo yokubilisa | °Cat760mmHg |
| PSA | 238.17000 |
| logP | -0.14090 |
| Ukunyibilika | H2O: 100mg/mL |
I-Citicoline (i-CDP-choline) ngumlamli oyintloko kwi-biosynthesis ye-phosphatidylcholine, inxalenye ebalulekileyo ye-neural cell membrane.Kuye kwaboniswa ukuvelisa imiphumo enenzuzo kuzo zombini iimodeli zezilwanyana kunye nezilingo zeklinikhi ezingezizo zase-US.Olu pho nonongo lubandakanya i-randomized (3 iidosi ze-citicoline kwi-1 placebo), ukulawulwa kwemoto, uvavanyo oluphindwe kabini kumaziko e-21 ase-US.Unyango lwaluza kuqalwa kwiiyure ezingama-24 emva kokuqala kwe-stroke kwaye lwaqhutyekwa ngomlomo kwiiveki ezi-6.Iziphumo zovavanyo lokugqibela bezikwiiveki ezili-12.Izigulane ezingamakhulu amabini anamashumi amahlanu anesithoba zabhaliswa, malunga nama-65 kwiqela ngalinye kula mane.Ixesha eliphakathi ukusuka ekuqaleni kwe-stroke ukuya kunyango ziiyure ze-14.5, kwaye kwakungekho nantlukwano ebalulekileyo kwiimpawu ezisisiseko phakathi kwamaqela amane ngaphandle kobunzima besigulane.Umahluko omkhulu phakathi kwamaqela, ukuthanda unyango lwe-citicoline, ubonwe ngokweziphumo zokusebenza njengoko kulinganiswe yi-Barthel Index kunye ne-Rankin isikali, uvavanyo lwe-neurologic njengoko lulinganiswe yi-National Institutes of Health (NIH) isikali sokubetha, kunye nomsebenzi wokuqonda njengoko kulinganiswe ngu. uVavanyo oluNcinci lwesimo seNgqondo.Xa isiseko se-NIH sokulinganisa i-stroke sisetyenziswe njenge-covariate, zombini i-500-mg yeqela le-citicoline kunye ne-2,000-mg yeqela le-citicoline libe nophuculo oluphawulekayo malunga neepesenti zezigulane ezinesiphumo esihle kwi-Index ye-Barthel kwiintsuku ze-90.Kwakungekho ziganeko ezimbi kakhulu ezinxulumene neziyobisi okanye ukufa kolu phononongo.Olu pho nonongo lubonisa ukuba i-citicoline yomlomo ingasetyenziselwa ngokukhuselekileyo kunye nemiphumo encinci yecala kwi-acute stroke treatment.I-Citicoline ibonakala iphucula umphumo osebenzayo kunye nokunciphisa i-neurologic deficit kunye ne-500 mg ye-citicoline ebonakala ngathi iyona dose efanelekileyo.
