Iimveliso

Ukutyeba ngokugqithiseleyo, uhlobo lwe-2 yeswekile kunye ne-hyperlipidemia zihlala zihlala kunye kwaye zihambelana nokunyuka kakhulu kokugula kunye nokufa.Ukusetyenziswa kwe-carbohydrate esulungekileyo kwaye ngakumbi i-fructose inyuke kakhulu kwiminyaka yakutshanje kwaye ihambelane nokwanda kwezehlo zokutyeba kunye nesifo seswekile.Izifundo zabantu kunye nezilwanyana zibonise ukuba ukutya okuphezulu kwe-fructose kuhambelana ngokufanelekileyo nokunyuka kwe-dyslipidemia, ukunganyangeki kwe-insulin, kunye noxinzelelo lwegazi.I-Metabolism ye-fructose yenzeka ikakhulu kwisibindi kwaye i-fructose ephezulu ikhokelela ekuqokeleleni kwe-hepatic triglyceride (i-hepatic steatosis).Oku kubangela ukuphazamiseka kwe-glucose kunye ne-lipid metabolism kunye nokunyuka kwe-proinflammatory cytokine expression.Apha sibonisa ukuba i-fructose iguqula i-glucose-stimulated expression of activated acetyl CoA carboxylase (ACC), pSer hormone sensitive lipase (pSerHSL) kunye ne-adipose triglyceride lipase (ATGL) kwi-HepG2 ye-hepatic okanye i-primary hepatic cell cultures in vitro.Oku kwakunxulunyaniswa nokunyuka kwe-de novo triglyceride synthesis in vitro kunye ne-hepatic steatosis kwi-vivo kwi-fructose- versus glucose-fed and standard-diet feeded mice.Ezi zifundo zibonelela ngengqiqo entsha kwiindlela ezibandakanyekayo kwi-fructose-mediated hepatic hypertriglyceridemia kunye nokuchonga i-fructose-uptake njengento entsha ekujoliswe kuyo yonyango yezifo ezinxulumene ne-lipid.