Ityuwa yeCarbenicillin disodium CAS: 4800-94-6 Emhlophe ukuya kumgubo omhlophe
| Inombolo Yekhathalogu | XD90371 |
| Igama lemveliso | Carbenicillin disodium ityuwa |
| CAS | 4800-94-6 |
| Ifomula yeemolekyuli | I-C17H16N2Na2O6S |
| Ubunzima beMolekyuli | 422.36 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29411000 |
Ukucaciswa kweMveliso
| pH | 5.5-7.5 |
| Umxholo wamanzi | ≤ 6.0% |
| Ukunyibilika | Isisombululo esicacileyo kunye nesityheli kancinane |
| Isivavanyi | 99% |
| Amandla | 830ug/mg |
| IiPyrogens | ≤ 80mg/kg |
| Ugqithiso | Iyahambelana |
| Imbonakalo | Umgubo omhlophe ukuya kumhlophe |
| Izinto zokufunxa iodine | ≤ 8.0% |
| Ibanga le-Usp | Iyahambelana |
| Uvavanyo (penicillin G) | Iyahambelana |
I-Cystic fibrosis sisifo sofuzo apho i-mucus engaqhelekanga emiphungeni inxulunyaniswa nokuba sesichengeni sosulelo oluzingileyo.Ukwanda kwemiphunga kuxa iimpawu zosulelo ziba qatha ngakumbi.Amayeza okubulala iintsholongwane ayinxalenye ebalulekileyo yonyango lokwandiswa kwaye amayeza okubulala iintsholongwane aphefumleyo anokusetyenziswa yedwa okanye ngokudityaniswa namayeza okubulala iintsholongwane ngomlomo ukwenzela ukunyusa okungephi okanye amayeza okubulala iintsholongwane emithanjeni yosulelo oluqatha.I-antibiotics e-inhaled ayibangeli iziphumo ezibi ezifanayo njenge-antibiotics ye-intravenous kwaye inokungqina enye indlela kubantu abanokufikelela kakubi kwimithambo yabo. isikolo okanye umsebenzi kunye nokuphucula ukusinda kwabo kwexesha elide.Siphendle i-ClinicalTrials.gov kunye ne-Australia kunye neNew Zealand ye-Clinical Trials Registry kwizilingo ezifanelekileyo.Umhla wophendlo lokugqibela: 15 Matshi 2012Sikwakhangele iRejista yeCystic Fibrosis Trials yeCochrane Cystic Fibrosis G roup.Umhla wokukhangela kokugqibela: 01 Juni 2012. Ulingo olulawulwa ngokungalindelekanga kubantu abane-cystic fibrosis kunye nokunyuka kwe-pulmonary apho unyango lwe-antibiotics oluphefumulelwe lufaniswa ne-placebo, unyango oluqhelekileyo okanye enye i-antibiotic e-inhaled phakathi kweveki enye neyesine. izilingo ezikhethiweyo ezifanelekileyo, zavavanya umngcipheko wokungakhethi kwilingo ngalinye kunye nedatha ekhutshiweyo.Ababhali bezilingo ezibandakanyiweyo baqhagamshelwe ngolwazi olungakumbi.Izilingo ezithandathu kunye nabathathi-nxaxheba be-208 zifakwe kuhlaziyo.Iimvavanyo zazingafani kuyilo kunye nongenelelo (nangona kunjalo, zonke zibandakanya iimvavanyo ezithelekisa ukuphefumlelwa ngokuchasene nerejimeni yesibulala-zintsholongwane).Umngcipheko womkhethe bekunzima ukuwuvavanya kulingo oluninzi.Iziphumo azizange zixelwe ngokupheleleyo kwaye kuphela idatha encinci yayifumaneka ukuze ihlalutywe.Ulingo olune lunike ingxelo yeziphumo ezithile kumthamo wokuphefumla ngenkani kwisekondi enye kwaye akukho mahluko ubalulekileyo phakathi kweyeza lokubulala iintsholongwane eliphefumlelweyo kunye nongenelelo lonyana oluthelekisayo.Kwiimvavanyo ezimbini zolu vavanyo zisebenzisa i-300 mg ye-tobramycin e-inhaled, utshintsho kwivolumu yokuphelelwa umoya ngenkani ngesekhondi enye yayifana ne-tobramycin ye-intravenous;kwaye kolunye ulingo ixesha kude kube kukwanda okulandelayo akuhlukanga.Akukho miphumo emibi ebalulekileyo echazweyo.Kukho ubungqina obuncinci obuphezulu obunobungqina bokugweba ukusebenza kwe-antibiotics ephefumulayo kunyango lwe-pulmonary exacerbations kubantu abane-cystic fibrosis.Ulingo olubandakanyiweyo aluzange lunikwe amandla ngokwaneleyo ukuphumeza iinjongo zabo.Ngenxa yoko, asikwazi ukubonisa ukuba olunye unyango lwaluyongamile kunolunye okanye akunjalo.Uphando olongezelelweyo luyafuneka ukufumanisa ukuba ingaba i-tobramycin efuthiweyo ingasetyenziswa njengenye indawo ye-tobramycin efakwa emthanjeni ukwenzela ukonyuka kwemiphunga ethile.
