I-Clozapine N-oxide CAS: 34233-69-7
| Inombolo Yekhathalogu | XD90469 |
| Igama lemveliso | I-Clozapine N-oxide |
| CAS | 34233-69-7 |
| Ifomula yeemolekyuli | C18H19ClN4O |
| Ubunzima beMolekyuli | 342.823 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29335990 |
Ukucaciswa kweMveliso
| Indawo yokunyibilika | 190-248 °C |
| Imbonakalo | Umgubo omhlophe |
| Isivavanyi | 99% |
Impembelelo engalunganga ibalulekile ekunikezeleni ukuba sesichengeni kumlutha we-opiate njengoko kubonakaliswa yi-comorbidity ephezulu yokusetyenziswa kakubi kwe-opiate kunye nengxaki enkulu yoxinzelelo (MDD).Iimodeli ze-rodent zibandakanya i-amygdala prodynorphin (Pdyn) njengomlamli wefuthe elibi;nangona kunjalo, ubungqina bokubandakanyeka kwe-PDYN kwimpembelelo embi yabantu kulinganiselwe.Apha, sifumene ukuchazwa kwePDYN mRNA kwi-postmortem ye-amygdala ye-nucleus yomntu ye-periamygdaloid cortex (PAC) kubo bobabini abaxhaphazi be-heroin kunye nezifundo ze-MDD.Ngokufana nabantu, iimpuku ezizilawulayo ngokuqhubekayo i-heroin ziye zanciphisa ukubonakaliswa kwe-Pdyn mRNA kwi-PAC ngexesha elihambelana nesimo esichaphazelekayo esibi.Ukusebenzisa itekhnoloji ye-imaging ye-vivo esebenzayo ye-DREAMM (i-DREADD-incedise kwimephu yemetabolism, apho i-DREADD ibonisa i-designer receptors eziye zavulwa ngokukodwa ngamachiza omyili), sifumanise ukuba inhibition ekhethiweyo ye-Pdyn-expressing neurons kwi-PAC yegundane yonyusa umsebenzi we-metabolic kwi-amygdala eyandisiweyo, eyandisiweyo. yinxalenye ephambili yenkqubo yoxinzelelo lwengqondo ye-extrahypothalamic.Ngokunxuseneyo, i-PAC-specific Pdyn inhibition ibangele utshintsho olubi olunxulumene nomzimba kunye nokuziphatha.Lilonke, uphononongo lwethu loguqulo luxhasa indima esebenzayo ye-Pdyn engalunganga kwi-PAC kukuxhatshazwa kwe-opiate ngokusebenza koxinzelelo kunye nefuthe elibi kwi-neurocircuitry ebandakanyeka kumngcipheko wokulutha.
