I-D-Leucine Cas: 328-38-1 99% Umgubo omhlophe
| Inombolo Yekhathalogu | XD90305 |
| Igama lemveliso | D-Leucine |
| CAS | 328-38-1 |
| Ifomula yeemolekyuli | C6H13NO2 |
| Ubunzima beMolekyuli | 131.17292 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29224985 |
Ukucaciswa kweMveliso
| Ukujikeleza okuthe ngqo | -14 ukuya -16 |
| AS | <1ppm |
| Pb | <10ppm |
| Ilahleko ekomisweni | <0.20% |
| Isivavanyi | 99% |
| Intsalela kwi-Ignition | <0.10% |
| Cl | <0.020% |
| Imbonakalo | Umgubo omhlophe |
Izinto ezisingqongileyo, ezifana nokubunjwa kwe-macronutrient yokutya, kunokuba nefuthe elibi kumngcipheko wesifo sikashukela kunye nesifo se-metabolic syndrome.Kuphononongo lwangoku sibonisa indlela enye, into elula yokutya--leucine--inokuguqula ukuxhathisa kwe-insulin ngokusebenza kwiithishu ezininzi kunye namanqanaba amaninzi e-metabolism.Iimpuku zafakwa kukutya okuqhelekileyo okanye okunamafutha aphezulu (HFD).I-leucine yokutya iphindwe kabini ngokongezwa kumanzi okusela.I-mRNA, iiprotheyini kunye neeprofayili ezipheleleyo ze-metabolomic zavavanywa kwizicubu eziphambili ze-insulin kunye ne-serum, kwaye zihambelana notshintsho kwi-glucose homeostasis kunye nokubonakaliswa kwe-insulin.Emva kweeveki ze-8 kwi-HFD, iigundane zavelisa ukukhuluphala, isibindi esinamafutha, utshintsho oluvuthayo kwizicubu ze-adipose kunye nokumelana ne-insulin kwinqanaba le-IRS-1 phosphorylation, kunye nokuguqulwa kweprofayili ye-metabolomic ye-amino acid metabolites, i-TCA cycle intermediates, i-glucose kunye ne-cholesterol metabolites. , kunye ne-fatty acids kwisibindi, imisipha, i-fat and serum.I-leucine yokutya ephindwe kabini ibuyise uninzi lwezinto ezingaqhelekanga ze-metabolite kwaye yabangela ukuphucuka okubonakalayo kokunyamezela iswekile kunye nokubonakaliswa kwe-insulin ngaphandle kokutshintsha ukutya okanye ukufumana ubunzima.Ukonyuka kwe-leucine yokutya kwayanyaniswa nokuncipha kwe-hepatic steatosis kunye nokuncipha kokuvuvukala kwizicubu ze-adipose.Olu tshintsho lwenzekile nangona ukwanda kwe-insulin-stimulated phosphorylation ye-p70S6 kinase ebonisa ukusebenza okuphuculweyo kwe-mTOR, into eqhelekileyo ehambelana nokuxhatshazwa kwe-insulin.Ezi datha zibonisa ukuba utshintsho oluthobekileyo kwindawo enye yokusingqongileyo / yezondlo lunokuguqula iindlela ezininzi ze-metabolic kunye nezibonakaliso kunye nokuguqula i-HFD ye-metabolic syndrome eyenziwa ngokusebenza kwinqanaba lenkqubo kwizicubu ezininzi.Ezi datha zikwacebisa ukuba ukonyuka kwe-leucine yokutya kunokubonelela nge-adjunct kulawulo lokunganyangeki kwe-insulin enxulumene nokutyeba.
