D-Valine Cas: 640-68-6 C5H11NO2
| Inombolo Yekhathalogu | XD90291 |
| Igama lemveliso | D-Valine |
| CAS | 640-68-6 |
| Ifomula yeemolekyuli | C5H11NO2 |
| Ubunzima beMolekyuli | 117.14634 |
| Iinkcukacha zokuGcina | ITemp yegumbi |
| IKhowudi yoMrhumo eHarmonized | 29224995 |
Ukucaciswa kweMveliso
| Isivavanyi | 99% |
| Imbonakalo | Umgubo omhlophe |
| Ukuxinana | 1.2000 (uqikelelo) |
| Indawo yokunyibilika | >295 °C (i-subl.) (isibane.) |
| Indawo yokubilisa | 213.6 °C ku-760 mmHg |
| Indawo yokuflasha | 83℃ |
| Isalathiso sokuqhafaza | -27 ° (C=8, 6mol/L HCl) |
| Ukunyibilika | 56 g/L (20°C) |
| Ukunyibilika kwamanzi | 56 g/L (20 ºC) |
| PSA | 63.32000 |
| LogP | 0.75460 |
| Ukujikeleza okuthe ngqo | -27.5 º (c=5, 5N HCl) |
| Umsebenzi wamehlo | [α]23/D −32.0 ukuya -24.0 °, c = 8 ku-6 M HCl |
Abasetyhini abane-antiphospholipid syndrome (APS) basengozini enkulu yokulahleka kokukhulelwa okuphindaphindiweyo (RPL) kunye ne-preeclampsia.I-Antiphospholipid antibodies (aPL) iguqula ngokuthe ngqo umsebenzi we-trophoblast.Unyango olunobunzima obuphantsi be-heparin (LMWH) yehlisa umngcipheko we-RPL kodwa hayi i-preeclampsia.Ngaphezu koko, i-LMWH ivuselela i-trophoblast sFlt-1 ukukhululwa, into echasene ne-angiogenic ehambelana ne-preeclampsia.Ekubeni ukusilela kwe-vitamin D kuhambelana ne-APS kunye ne-preeclampsia, olu pho nonongo lufuna ukufumanisa umphumo we-vitamin D kumsebenzi we-trophoblast kwindawo yokumisela i-aPL kunye ne-LMWH.A umntu wokuqala we-trimester trophoblast cell line (HTR8) kunye neenkcubeko zetrophoblast eziphambili zaphathwa okanye ngaphandle kwe-aPL kubukho kunye nokungabikho kwevithamini D, LMWH okanye zombini.I-Trophoblast secretion ye-cytokines evuthayo kunye nezinto ze-angiogenic zilinganiswa ngu-ELISA.I-Vitamin D yodwa okanye idibene ne-LMWH igxininise i-aPL-induced trophoblast impendulo yokuvuvukala kwiiseli ze-HTR8 kunye neenkcubeko eziphambili.Nangona i-vitamin D yayingenayo nayiphi na impembelelo kwi-aPL-mediated modulation of angiogenic factor in the primary trophoblast, inhibited kakhulu i-LMWH-induced sFlt-1 ukukhululwa.LMWH ngokudibanisa ne-vitamin D kunokuba luncedo kunonyango lwe-agent enye ngokuthintela i-aPL. -i-trophoblast eyenzelwe ukuvuvukala kunye nokuguqula i-LMWH-induced sFlt-1 secretion.
