I-Diethylene triamine pentaacetic acid Cas: 67-43-6 99% Umgubo omhlophe wekristale
| Inombolo Yekhathalogu | XD90220 |
| Igama lemveliso | I-Diethylene triamine pentaacetic acid |
| CAS | 67-43-6 |
| Ifomula yeemolekyuli | I-C14H23N3O10 |
| Ubunzima beMolekyuli | 393.3465 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29224985 |
Ukucaciswa kweMveliso
| Iintsimbi ezinzima | 0.001% ubukhulu |
| pH | 2 - 3 |
| Fe | 0.001% ubukhulu |
| Ukunyibilika | Ukunyibilika kancinci emanzini, isisombululo se-15% sinyibilika emanzini ashushu.Inyibilika kuyo yonke iAlkali |
| Isivavanyi | 99% imizuzu |
| Uthuthu olufakwe emanzini | 0.1% ubukhulu |
| Cl | 0.1% ubukhulu |
| Imbonakalo | Umgubo omhlophe wekristale |
Ukunyuka koxinzelelo lwe-oxidative phantsi kweemeko ze-hyperglycemic, ngokusebenzisana kwe-AGEs kunye ne-RAGE receptors kunye nokusebenzisa i-interleukin mediated transcription signalling, kuye kwabikwa kumhlaza.Ukuguqulwa kweeprotheyini kuphononongwa kwiindima zabo kuphuhliso kunye nokuqhubekela phambili komhlaza kwaye impendulo ye-autoantibody ngokuchasene nabo ifumana umdla njengophando lokubhaqwa kwangoko kwesi sifo.Olu pho nonongo luhlalutye utshintsho kwi-histone H1 phezu kokuguqulwa kwe-methylglyoxal (MG) kunye nefuthe layo kwi-auto-immunopathogenesis yomhlaza.I-histone elungisiweyo ibonise uhlengahlengiso kwiintsalela ezinevumba elimnandi, yatshintsha i-tyrosine microenvironment, i-intermolecular cross linking kunye nesizukulwana see-AGEs.Ibonise ukufihlakala kweepatches ze-hydrophobic kunye nokutshintsha kwe-hypsochromic kwi-ANS ethile ye-fluorescence.I-MG i-oxidized histone H1 ngokukrakra ekhokelela ekuqokeleleni kweekhabhoni ezisebenzayo.Imilinganiselo yeCD ye-UV ekude ibonise ukuphuculwa kwe-di-carbonyl ye-alpha kunye nokufakwa kwe-beta sheet conformation;kunye nezifundo ze-thermal denaturation (Tm) ziqinisekisile ukuzinza kwe-thermal ye-histone elungisiweyo.Uhlalutyo lwe-FTIR lubonise i-amide I band shift, isizukulwana seqela le-carboxyethyl kunye ne-N-Cα vibrations kwi-histone elungisiweyo.Uhlalutyo lwe-LCMS luqinisekisile ukusekwa kwe-Nε-(carboxyethyl)lysine kunye nezifundo ze-electron microscopic zibonise ukubunjwa kwe-amorphous aggregate.I-histone elungisiweyo ibonise ukudityaniswa kwentsebenziswano kunye neDNA.I-H1 elungisiweyo iye yavelisa izilwa-buhlungu ze-titre ephezulu kwimivundla kunye ne-IgG yefom eyodwa yesera yemivundla egonywe nge-H1 elungisiweyo ebonisa ukubophelela okuthe ngqo kunye ne-immunogen yayo kuhlalutyo lwe-Western Blot.I-IgG ibekwe yodwa kwisera yezigulana ezinomhlaza wemiphunga, umhlaza wedlala lobudoda, umhlaza wamabele kunye nomhlaza wentloko kunye nentamo ibonise ukuqondwa ngcono kwe-neo-epitopes kwi-histone elungisiweyo, ebonisa ubukho be-autoantibodies kumhlaza.Kuba iingxelo zibonisa unxibelelwano phakathi kwe-AGE-RAGE axis kunye ne-carcinogenesis, i-glycoxidation ye-histone H1 kunye nokukhuseleka kwayo kuvula iindlela zokuqonda indima ye-glycoxidatively eyonakeleyo yeeproteni zenyukliya kumhlaza.
