I-5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 Emhlophe ukuya kwikristale emhlophe
| Inombolo Yekhathalogu | XD90230 |
| Igama lemveliso | 5-Sulfosalicylic acid dihydrate |
| CAS | 5965-83-3 |
| Ifomula yeemolekyuli | I-C7H10O8S |
| Ubunzima beMolekyuli | 254.215 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29182900 |
Ukucaciswa kweMveliso
| Sulfate | 5.5% ubukhulu |
| Ukufuma | 22% max |
| Imbonakalo | Emhlophe ukuya kwikristale emhlophe |
| Iasidi iyonke | 99 - 104% |
| Isivavanyi | 99% |
Iipolycation zijongwa njengabathwali bokuhambisa i-nucleic acids yonyango.Iipolycations ngokuqhelekileyo inert ye-pharmacological kunye nomsebenzi owodwa wokuhambisa imithwalo yonyango.Olu pho nonongo luxela ukuhlanganiswa kwepolycation ye-self-immolative (DSS-BEN) esekelwe kwi-polyamine analogue drug N (1), N (11) -bisethylnorspermine (BENSpm).I-polycation yayiyilwe ukuba isebenze ngokuphindwe kabini njengomthwali wokuhanjiswa kwemfuza kunye neprodrug ejolise kwi-dysregulated polyamine metabolism kumhlaza.Ukusebenzisa indibaniselwano ye-NMR kunye ne-HPLC, siqinisekisa ukuba i-polycation ye-self-immolative idlula kwi-intracellular degradation kwiyeza lomzali i-BENSpm.I-BENSpm ekhutshweyo ichitha amanqanaba eselula e-spermidine kunye ne-spermine kwaye iphakamisa i-polyamine catabolic enzymes i-spermine / spermidine N (1) -acetyltransferase (SSAT) kunye ne-spermine oxidase (SMO).Iipolycations ezidibeneyo zenza i-polyplexes kunye ne-DNA kwaye iququzelele ukudluliselwa okusebenzayo.Ukuthatha ithuba lokukwazi kwe-BENSpm ukwazisa iiseli zomhlaza kwi-apoptos ye-TNFα-induced, sibonisa ukuba i-DSS-BEN iphucula umsebenzi wokubulala iiseli ze-TNFα gene therapy.Iziphumo ezichaziweyo ziqinisekisa i-DSS-BEN njengenkqubo yokuhanjiswa kwemisebenzi emibini enokuthi inike imfuza yonyango kwaye iphucule isiphumo sonyango lwemfuza njengesiphumo sokuthotywa kwe-intracellular ye-DSS-BEN ukuya kwi-BENSpm kunye nesiphumo esiluncedo esilandelayo se-BENSpm kwi-polyamine engasebenziyo. imetabolism kumhlaza.
