I-Fast Blue RR Ityuwa ye-CAS: 14726-29-5
| Inombolo Yekhathalogu | XD90515 |
| Igama lemveliso | Fast Blue RR Ityuwa |
| CAS | 14726-29-5 |
| Ifomula yeemolekyuli | I-C30H28Cl4N6O6Zn |
| Ubunzima beMolekyuli | 491.49 |
Ukucaciswa kweMveliso
| Isivavanyi | 99% |
Isiphumo esingalindelekanga sezinye iiklasi ze-anticoagulants ibe yi-osteoporosis enokuthi, ubuncinane ngokuyinxenye, inxulumene nomsebenzi we-mesenchymal stem cell (MSC).Injongo yolu phononongo yangoku yayikukuthelekisa umphumo we-fondaparinux (FDP), inoveli ye-antithrombotic ene-heparin ye-molecular esetyenziswa ngokubanzi ephantsi, i-tinzaparin (TZP) kwi-MSC yokwandisa kunye nokwahlula.Ii-MSC zahlukaniswa kwithambo le-trabecular yezigulane ze-14 ze-trauma ngenkqubo yokugaya i-collagenase-based based digestion kwaye yandiswa kwiimeko eziqhelekileyo ukuya kwi-3. uvavanyo kunye noluhlu olubanzi lokugxilwa kweziyobisi.I-flow cytometry yasetyenziswa kwi-MSC phenotyping.Kwiqela elifundwayo elidala (iminyaka eyi-17-74 ubudala) i-frequency ye-MSC kwi-collagenase-released fractions yayiyi-641 / 10 (6) iiseli (uluhlu lwe-110-2,158) kunye neempawu zabo zokukhula zaziyi--4 iintsuku / ukuphindaphinda kwabemi.Iinkcubeko zine-phenotype ye-MSC eqhelekileyo (CD73+, CD105+, CD146+, CD106+, kunye ne-CD166+).Ukwanda kweeseli kwavavanywa yi-colon-forming unit-fibroblast (CFU-F) kunye ne-colorimetric tetrazolium ityuwa ye-XTT assays.Kuzo zombini iimvavanyo, ukwanda kwe-MSC kwathintelwa kokongezwa kwe-TZP, ngakumbi kwiindawo eziphezulu.Ngokuchaseneyo, i-FDP ayizange ibe nefuthe ekwandeni kwe-MSC.Ukwahlula kwe-Osteogenic kunye nokwahlula kwe-chondrogenic akuzange kuchaphazeleke ngokongezwa kwe-TZP okanye i-FDP.Ngelixa ukwanda kwe-MSC, kodwa ingelulo ulwahlulo, kuchatshazelwa kakubi yi-TZP, kwakungekho bungqina beziphumo ezibi ze-FDP kule nkqubo yemodeli ye-in vitro exoxa kakuhle ngokusetyenziswa kwayo kwimeko ye-orthopedic.
