I-Folic Acid Cas: 59-30-3 99%
| Inombolo Yekhathalogu | XD90435 |
| Igama lemveliso | Ifolic acid |
| CAS | 59-30-3 |
| Ifomula yeemolekyuli | C19H19N7O6 |
| Ubunzima beMolekyuli | 441.40 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29362900 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo wekristale otyheli okanye orenji |
| Isivavanyi | 99% |
| Amanzi | 5.0 - 8.5% |
| Ukucoceka kweChromatographic | <2.0% |
| Ukunyibilika | Ngokuqhelekileyo ayinyibiliki emanzini nakwizinyibilikisi ezininzi zendalo.Iyinyibilika kwi-acids dilute kunye nakwizisombululo ze-alkaline |
| Intsalela kwi-Ignition | <0.3% |
Kolu phononongo, i-thermosensitive kunye ne-folate functionalized poly(ethylene oxide) -b-poly(propylene oxide) -b-poly(ethylene oxide) -ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) icopolymer yaba idityanisiwe.Ubume kunye nobunzima be-molecular ye-copolymer buqinisekiswe yi-1H NMR, FT-IR kunye ne-GPC, ngokulandelanayo.Iqondo lokushisa elisezantsi elibalulekileyo (LCST) le-copolymer laliyi-39.8 degrees C. Ngokusebenzisa i-doxorubicin (DOX) njengeyeza lomzekelo, i-folate receptor-targeted DOX-loaded micelles yenziwa ngakumbi kwi-copolymer.Iimicelles ezingenanto kunye ne-DOX-zilayishwe zombini zibonise iimilo eziphantse zibe ngqukuva kwaye i-avareji yazo idayamitha yayiyi-35 nm kunye ne-50 nm, ngokulandelelanayo.Ukuziphatha kokukhutshwa kwe-in vitro yee-micelles ezilayishwe yi-DOX zazixhomekeke kwiqondo lokushisa kwaye izinga lokukhululwa kwe-DOX kwi-42 degrees C (ngaphezu kwe-LCST) yayikhawuleza ngaphezu kwe-37 degrees C (ngaphantsi kwe-LCST).Ngaphaya koko, uvavanyo lwe-cytotoxicity lwe-DOX yasimahla kunye ne-DOX-micelles elayishiweyo kwimigca yeeseli zomhlaza womlomo wesibeleko i-HeLa kunye nemigca yeseli yomhlaza wemiphunga yomntu i-A549 ibonise ukuba i-folate yonyuse ukuthatyathwa kweeseli zemicelles ngaphakathi kweeseli ekujoliswe kuzo ezibonisa kakhulu i-folate receptors.
