Iimveliso

I-Islet amyloid polypeptide (IAPP; ekwabizwa ngokuba yi-amylin) inoxanduva lokuqulunqwa kwe-islet amyloid kuhlobo lwe-2 yeswekile, kwaye i-IAPP-induced toxicity ikholelwa ukuba inegalelo ekulahlekeni kwe-β-cell mass ehambelana nezigaba zokugqibela zohlobo lwe-2 yeswekile.Ukwakhiwa kwe-Islet amyloid kunokudlala indima ekungaphumeleli kwe-graft emva kokutshintshwa.I-IAPP iveliswa njengeprohormone, ipro-islet amyloid polypeptide (proIAPP), kwaye icutshungulwe kwi-secretory granules ye-pancreatic β-cell.Iifomu ezicutshungulwe ngokuyinxenye zeproIAPP zifumaneka kwiidiphozithi ze-amyloid;eyona nto iphawulekayo yi-48-residue intermediate, i-proIAPP(1-48), ebandakanya i-N-terminal pro-extension, kodwa eqhutywe ngokufanelekileyo kwi-C-terminus.Ukucutshungulwa okungaphelelanga kunokudlala indima ekubunjweni kwe-islet amyloid ngokukhuthaza ukusebenzisana kunye ne-sulfate proteoglycans ye-matrix ye-extracellular, leyo, emva koko, ikhuthaza ukubunjwa kwe-amyloid.Sibonisa ukuba i-acid fuchsin (3- (1- (4-amino-3-methyl-5-sulphonatophenyl) -1- (4-amino-3-sulphonatophenyl) methylene) cyclohexa-1,4-dienesulphonic acid), elula I-sulfonated triphenyl methyl derivative, i-inhibitor enamandla yokwakheka kwe-amyloid yi-proIAPP (1-48) ephakathi.Eyona nto intsonkothe ​​ngakumbi i-triphenyl methane derivative eluhlaza ekhawulezayo ye-FCF {ethyl-[4-[[4-ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa -2,5-dienylidene]-[(3-sulfophenyl)methyl]azanium} iphinda inqanda ukubunjwa kwe-amyloid yi-IAPP kunye neproIAPP processing intermediate.Zombini iikhompawundi zithintela ukwakheka kwe-amyloid ngemixube ye-proIAPP ephakathi kunye nemodeli ye-glycosaminoglycan heparan sulfate.I-Acid fuchsin iphinda inqande ukubunjwa kwe-amyloid ye-glycosaminoglycan nge-IAPP ekhulileyo.Ukukwazi ukuvimbela ukubunjwa kwe-amyloid akukona nje ngenxa yokuba i-compounds i-sulfonated, ekubeni i-sulfonated inhibitor ye-amyloid-β, i-tramiprosate, ayikho inhibitor yokwakheka kwe-amyloid nge-proIAPP (1-48).