I-Furazolidone Cas: 67-45-8
| Inombolo Yekhathalogu | XD91885 |
| Igama lemveliso | I-Furazolidone |
| CAS | 67-45-8 |
| Ifomu yemolekyulila | C8H7N3O5 |
| Ubunzima beMolekyuli | 225.16 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29349990 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo otyheli |
| uAsay | 99% imizuzu |
| Indawo yokunyibilika | 254-256°C (dec.) |
| Indawo yokubilisa | 366.66°C (uqikelelo olurhabaxa) |
| ukuxinana | 1.5406 (uqikelelo olurhabaxa) |
| isalathiso se-refractive | 1.7180 (uqikelelo) |
| Fp | 2 °C |
| ukunyibilika | formic acid: i-soluble50mg/mL |
| pka | -1.98±0.20(Kuxelwe kwangaphambili) |
| Inovakalelo | Ukukhanya okunovelwano |
| λmax | 365nm(DMSO)(lit.) |
| Uzinzo | Izinzile.Ukutsha.Ayihambelani ne-oxidizing agents ezinamandla. |
I-antibacterial spectrum ye-furazolidone ifana ne-furazolidone.Njengechiza elichasayo, lisebenza kakuhle ekunyangeni iSalmonella, Shigella, Escherichia coli, Proteus, Streptococcus, kunye neStaphylococcus aureus.Iintsholongwane akukho lula ukuphuhlisa ukunganyangeki kumachiza kweli chiza.Kananjalo ayinayo ukuxhathisa kuluhlu lwe-sulfa antibiotics.Isetyenziselwa ikakhulu unyango lwezonyango lwe-dysentery, enteritis, typhoid, paratyphoid kunye nonyango lwe-vaginal trichomoniasis.
2. Imveliso yi-fungicide ene-antibacterial spectrum ebanzi.Njengechiza elichasayo, liyasebenza ekunyangeni iintlobo ngeentlobo zebhaktiriya e-Gram-positive kunye ne-negative kuquka i-Escherichia coli, i-Bacillus anthracis, kunye ne-Paratyphoid bacilli.Ayisebenzi kuphela kunyango lwe-dysentery, enteritis, kodwa isetyenziselwa ukunyanga izifo zangasese.Kwiminyaka yakutshanje, inokusebenza kakuhle kunyango lwe-typhoid fever.Njengesongezo seziyobisi zezilwanyana kunye nesiselo, sinempembelelo ekhethekileyo ye-antibacterial kwi-Salmonella, i-Escherichia coli kunye ne-Salmonella pullorum kwaye inefuthe elithile lokuthintela kwi-protozoa (i-coccidia bacteria, njl.)Inani elincinci le-furazolidone lisetyenziselwe ezinye izicelo (ezifana nepeyinti e-soluble yamanzi kunye ne-pulp yephepha) njenge-fungicides.
3. Lichiza elichasayo elisetyenziselwa ukuchasana nokusuleleka kwamathumbu.
4. I-Furazolidone, njenge-fungicide, ine-antibacterial spectrum ebanzi.Eyona bhaktiriya esemngciphekweni yiEscherichia coli, Bacillus anthracis, paratyphoid rod, Shigella, kunye neKlebsiella pneumoniae.I-Salmonella typhi nayo inovelwano kuyo.Isetyenziselwa ikakhulu ukunyanga isifo se-dysentery, i-enteritis, kunye nekholera.Ingasetyenziselwa ukunyanga i-typhoid, i-paratyphoid, i-giardiasis, kunye ne-trichomoniasis.Ukudibanisa kunye neziyobisi ezichasene ne-asidi zingasetyenziselwa ukunyanga i-Helicobacter pylori-induced gastric inflammation.Iipropati: umgubo omthubi okanye umgubo wekristale, ongenavumba, kuqala awunancasa kwaye emva koko ube krakra kancinci;kancinane kakhulu ukunyibilika emanzini kunye ne-ethanol;Inyibilika kancinane kwichloroform kwaye ayinyibiliki kwi-ether, inyibilika kwidimethylformamide kunye nenitromethane.Mp: 255 ukuya 259 °C.Ukubola ngelixa ukupheliswa.
I-Furazolidone isetyenziselwa izifo zesisu kunye ne-vaginitis.Isetyenziselwa ikakhulu kumazwe asakhasayo ukunyanga izifo zorhudo ze-etiology ehlukeneyo, kodwa akusiyo iyeza elikhethiweyo ukuba i-pathogen ethile ichongiwe.Sebenzisa njenge-agent ye-secondline kwi-giardiasis kwaye njengenxalenye ye-multidrug regimens kwi-Helicobacter usulelo luye lwakhuthazwa.
3 - [(5-Nitrofurylidene) amino] -2-oxazolidinone (Furoxone) yenzeka njenge powder crystalline ephuzi kunye ne-aftertaste ekrakra.Ayinyibiliki emanzini okanye etywaleni.I-Furazolidone inomsebenzi we-bactericidal ngokuchasene noluhlu olubanzi lwe-intestinal pathogens, kuquka i-S. aureus, i-E. coli, i-Salmonella, i-Shigella, i-Proteus spp., i-Enterobacter, kunye ne-Vibrio cholerae.Ikwasebenza ngokuchasene ne-protozoan Giardia lamblia.Kucetyiswa kunyango lomlomo lwebhaktiriya okanye iprotozoal diarrhea ebangelwa zizidalwa ezithintekayo.Idosi eqhelekileyo yabantu abadala yi-100 mg ngamaxesha e-4 yonke imihla.
Kuphela iqhezu elincinci lomthamo olawulwa ngomlomo we-furazolidoneis efunnyiweyo.Phantse i-5% yedosi yomlomo ibonakala kumchamo ngendlela yee-metabolites ezininzi.Okunye ukuphazamiseka kwesisu kuye kwabikwa ngokusetyenziswa kwayo.Utywala kufuneka buphetshwe xa kusetyenziswa i-furazolidone kuba ichiza linokuthintela i-aldehyde dehydrogenase.
