Ivermectin Cas: 70288-86-7
| Inombolo Yekhathalogu | XD91886 |
| Igama lemveliso | Ivermectin |
| CAS | 70288-86-7 |
| Ifomu yemolekyulila | C48H74O14 |
| Ubunzima beMolekyuli | 875.09 |
| Iinkcukacha zokuGcina | 2-8°C |
| IKhowudi yoMrhumo eHarmonized | 29322090 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe |
| uAsay | 99% imizuzu |
| alpha | D +71.5 ± 3 ° (c = 0.755 kwiklorofomu) |
| RTECS | IH7891500 |
| ukunyibilika | H2O: ≤1.0% KF |
| Ukunyibilika kwamanzi | 4mg/L(iqondo lobushushu alichazwanga) |
Ivermectin (Cardomec, Eqvalan, Ivomec) ngumxube we-22,23-dihydro derivatives ye-avermectins B1a kunye ne-B1belungiselelwe yi-catalytic hydrogenation.I-Avermectins ngamalungu osapho lwamayeza okubulala iintsholongwane ngokwesakhiwo aveliswa ngokubiliswa ngoxinzelelo lweStreptomycesavermitilis.Ukufunyaniswa kwabo kube ngumphumela wovavanyo olunzulu lweenkcubeko zee-anthelmintic agents ezivela kwimithombo yendalo.Ivermectin iyasebenza kwidosi ephantsi ngokuchasene neentlobo ngeentlobo ze-nematodes kunye ne-arthropods ukuba i-parasitizeanimals.
Ivermectin iphumelele ukusetyenziswa ngokubanzi kwizilwanyana eUnited States kunye namazwe amaninzi ehlabathini lonke ukulawula endoparasites kunye ectoparasitesin izilwanyana zasekhaya.Ifunyaniswe isebenzayo kunyango lwe-onchocerciasis ("ubumfama bomlambo") ebantwini, isifo esibalulekileyo esibangelwa yi-roundwormOncocerca volvulus, exhaphake eNtshona nakuMbindi Afrika, kuMbindi Mpuma, nakuMzantsi noMbindi Merika.Ivermectin itshabalalisa i-microfilariae, engekavuthwa. Iintlobo zenematode, ezidala ulusu kunye namaqhuqhuva ezicubu eziluphawu lohlaselo kwaye zinokukhokelela kubumfama. Ikwanqanda ukukhutshwa kwemicrofilariae yiintshulube zabantu abadala ezihlala kwindawo leyo.Uphononongo ngendlela yesenzo se-ivermectin lubonisa ukuba ivala usasazo lwe-interneuron-motor neuron kwi-nematodes ngokuvuselela ukukhutshwa kwe-GABA ye-neurotransmitter ethintelayo.
Ivermectin inomsebenzi obanzi wokuba inokuchaphazela i-nematodes, inambuzane, kunye ne-acarine parasites.Lichiza elikhethiweyo kwi-onchocerciasis kwaye liluncedo kakhulu kunyango lwezinye iintlobo ze-filariasis, i-strongyloidiasis, i-ascariasis, i-loiasis, kunye ne-cutaneous larva migrans.Ikwasebenza kakhulu kwiingolwane ezahlukeneyo.Lichiza elikhethwayo ekunyangeni abantu abosulelwe yi-Onchocerca volvulus, lisebenza njengechiza le-microfilaricidal ngokuchasene nemibungu ehlala eluswini (microfilaria).Unyango lonyaka lunokuthintela ubumfama kwi-ochocerciasis yamehlo.I-Ivermectin icacile ngakumbi kune-diethylcarbamazine kwi-bancroftian filariasis, kwaye iyanciphisa i-microfilaremia ukuya kumanqanaba angaphantsi kwe-zero.Kwi-brugian filariasis i-diethylcarbamazine-i-induced clearance ingaba phezulu.Ikwasetyenziselwa ukunyanga imibungu efudukayo kunye nokusabalalisa i-strongyloidiasis.Ukusetyenziswa kwayo ngokukhuselekileyo ekukhulelweni akukasekwa ngokupheleleyo.
