Gentamycin Sulfate CAS:1405-41-0 Umgubo omhlophe
| Inombolo Yekhathalogu | XD90364 |
| Igama lemveliso | Gentamycin sulfate |
| CAS | 1405-41-0 |
| Ifomula yeemolekyuli | I-C21H43N5O7H2So4 |
| Ubunzima beMolekyuli | 575.68 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29419000 |
Ukucaciswa kweMveliso
| Amanzi | 15% max |
| pH | 3.5-5.5 |
| Isivavanyi | 590IU/mg min |
| Ukujikeleza okuthe ngqo | +107 ° ukuya +121 ° |
| Imbonakalo | Umgubo omhlophe |
| Isulfate (SO4) | 32 - 35% |
| Uthuthu olufakwe emanzini | <1.0% |
Ukulimala kwentambo yomgogodla odibeneyo kuyinkimbinkimbi ngenxa yokulibaziseka kokulahlekelwa kwe-oligodendrocytes, okubangelwa ukuchithwa okungapheliyo okuqhubekayo.Ngoko ke, izicwangciso zokutshintshwa kwe-oligodendrocyte kunye nokuphucula ubungakanani be-myelination kubonakala kulungele ukulungiswa kwentambo yomgogodla.Uphononongo lwangoku luphande ukuba ngaba ukutshintshwa kweeseli ze-neural stem cells (NSCs) ziguqulwe ngokwemfuza ukuze zichaze i-Olig2 transcription factor, umlawuli obalulekileyo wophuhliso lwe-oligodendrocyte, inokuphucula ukubuyiswa kwe-locomotor kunye nokuphucula i-myelination kwimodeli yokulimala kwe-rat contusive.HB1.F3 (F3) ) Umgca we-NSC ongafiyo watshintshwa kunye ne-retroviral vector encoding Olig2, umlawuli obalulekileyo wophuhliso lwe-oligodendrocyte.Ukugqithiswa kwe-Olig2 kwii-NSC zabantu (F3.Olig2) yenze ukuba kusebenze i-NKX2.2 kwaye iqondise ukuhlukana kwee-NSC kwiiseli zomgca we-oligodendrocyte kwi-vitro.Ukuqaliswa kwe-Olig2 kunikeze umsebenzi ophezulu wokwandisa, kunye nenani elikhulu kakhulu le-F3.Olig2 NSCs lifunyenwe kwiiveki ze-7 emva kokutshintshwa kwintambo yomgogodla ephazamisayo kunee-NSC ze-F3 zabazali.Ii-F3.Olig2 NSCs zibonise ukufuduka rhoqo ukuya kumbandela omhlophe, ngelixa i-F3 NSCs ubukhulu becala bezivaleleke kwigreyi okanye kwimingxuma yesilonda.Uninzi lwee-NSC ze-F3.Olig2 ezithatha into emhlophe egciniweyo yahlulwe kwi-oligodendrocytes eqolileyo.Ukutshintshwa kwe-F3.Olig2 NSCs kwandisa umthamo wezinto ezimhlophe ezigciniweyo kunye nokunciphisa umthamo we-cavity.Ngaphezu koko, iigrafti ze-F3.Olig2 zandisa kakhulu ubukhulu be-myelin sheath ejikeleze i-axons kumbandela omhlophe ogciniweyo.Ekugqibeleni, izilwanyana ezine-F3.Olig2 grafts zibonise ukuphuculwa komgangatho we-hindlimbs locomotion.Ukutshintshwa kwee-NSCs zokuguqulwa kofuzo ukuze zihluke kwi-oligodendrocytic lineage ingaba sisicwangciso esisebenzayo sokuphucula iziphumo zokusebenza emva kokulimala komgogodla.Uphononongo lwangoku lucebisa ukuba imiba yeemolekyuli elawula izigqibo zeseli yekamva inokuguqulwa ukuze kuphuculwe amandla okubuyisela kunyango olusekwe kwiseli.
