Xa kukho i-2.8 mM D-glucose, i-beta-D-glucose pentaacetate (1. 7 mM) i-insulin eyandisiweyo yokukhululwa kwi-rat pancreatic islets eyedwa ngaphezu kwe-alpha-D-glucose pentaacetate.Ngokunjalo, ukonyuka okungaphaya kwimveliso ye-insulin evuswe yi-nateglinide (0.01 mM) ibiphezulu kwiziqithi ezivezwe kwi-beta kune-alpha-D-glucose pentaacetate.Ngokuchaseneyo, phambi kwe-2.8 mM ye-D-glucose engaqinisekanga, i-alpha-L-glucose pentaacetate, kodwa kungekhona i-beta-L-glucose pentaacetate, i-insulin eyandisiweyo kakhulu.Amandla aphezulu e-insulinotropic ye-beta-anomer ye-D-glucose pentaacetate angqamene nento yokuba inyuse kakhulu umlinganiselo odityanisiweyo phakathi kwe-D- [U-14C] ne-glucose oxidation kunye ne-D- [5-3H] nokusetyenziswa kweglucose, ngelixa i-alpha-D -i-glucose pentaacetate ayiphumelelanga ukwenza njalo.Ezi ziphumo zitolikwa ukuxhasa ingcamango yokuba ukukhuthazwa kokukhululwa kwe-insulin ngala ma-esters kubangelwa kakhulu ukusebenzisana kwabo ngokuthe ngqo kunye ne-receptor ye-stereospecific, ngokukhetha ukulungiswa kwe-C1 eqhelekileyo kwi-beta-D-glucose pentaacetate kunye ne-alpha-L- i-glucose pentaacetate.
