I-Glutathione yanciphisa i-Cas: 70-18-8 98-101% Ecacileyo kwaye ayinambala
| Inombolo Yekhathalogu | XD90284 |
| Igama lemveliso | I-Glutathione iyancipha |
| CAS | 70-18-8 |
| Ifomula yeemolekyuli | I-C10H17N3O6S |
| Ubunzima beMolekyuli | 307.32 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 29309098 |
Ukucaciswa kweMveliso
| Isivavanyi | 98% - 101% |
| Imbonakalo | Umgubo omhlophe wekristale |
| IBanga | EP 7.0 |
| Ukungcola A | <0.5% |
| Ukungcola B | <0.5% |
| Iintsimbi ezinzima | <10ppm |
| I-endotoxin yebhaktheriya | <0.10EU/mg |
| Ukungcola C | <1.5% |
| Ukungcola D | <1.0% |
| Ilahleko ekomisweni | <0.5% |
| Ukunyibilika | Inyibilika ngokukhululekileyo emanzini, i-soluble kancinane kwi-ethanol kunye ne-methylene chloride |
| Intsimbi | <10ppm |
| Iikloridi | <200ppm |
| Imbonakalo yesisombululo | Icacile kwaye ayinambala |
| Ukujikeleza okuthe ngqo | -15.5 ukuya -17.5 |
| Ukungcola ngokupheleleyo | <2.5% |
| Ammonium | <200ppm |
| Uthuthu olufakwe emanzini | <0.1% |
| Iisulfates | <300ppm |
| Ukungcola E | <0.5% |
Ukuguqulwa kweprotheyini emva kokuguqulelwa, njenge-tyrosine phosphorylation, ilawula i-protein-protein interactions (PPIs) ibaluleke kakhulu ekusebenzeni komqondiso kunye ne-phenotypes yeselula.Sandisa igwele elimiselweyo inkqubo ye-hybrid-hybrid esebenzisa iprotein kinases yomntu kuhlalutyo lwee-PPI ezixhomekeke kwi-phospho-tyrosine (pY) kwindlela yokuvavanya ngokuthe ngqo, indlela enkulu.Sichonge i-292 ikakhulu i-PPIs exhomekeke kwi-PY ebonisa ukuchaneka okuphezulu ngokubhekiselele kwi-kinases kunye neeprotheni ezisebenzisanayo kunye nokuqinisekiswa kweqhezu elikhulu kwiimvavanyo ze-co-immunoprecipitation ezivela kwiiseli ze-mammalian.Malunga nesinye kwisithandathu sonxibelelwano lulungelelaniswe ziimotifs ezibophelelayo ngolandelelwano olulandelelanayo ngelixa uninzi lwe-pY-PPIs luphakathi kwezinye ii-epitopes ezinomgca okanye zilawulwa zezinye iindlela zokuqaphela.Uhlalutyo lwenethiwekhi lubonakalise ukuba iziganeko zokuqaphela i-pY-mediated zibotshelelwe kwimodyuli yeprotheyini eqhagamshelene kakhulu ezinikele ekuboniseni kunye neendlela zokukhula kweeseli ezinxulumene nomhlaza.Ukusebenzisa ii-assays ezibophelelayo, iprotein complement ntation kunye ne-phenotypic readouts ukubonisa intsebenziswano exhomekeke kwi-pY ye-TSPAN2 (tetraspanin 2) kunye ne-GRB2 okanye i-PIK3R3 (p55γ), sinika umzekelo wobungqina bokuba ii-PPI ezimbini ezixhomekeke kwi-pY zilawula i-phenotypes yomhlaza weselula.
