I-Guanosine-5'-diphosphate, ityuwa ye-disodium Cas: 7415-69-2 Umgubo omhlophe 98%
| Inombolo Yekhathalogu | XD90756 |
| Igama lemveliso | I-Guanosine-5'-diphosphate, ityuwa ye-disodium |
| CAS | 7415-69-2 |
| Ifomula yeemolekyuli | I-C10H13N5Na2O11P2 |
| Ubunzima beMolekyuli | 487.16 |
| Iinkcukacha zokuGcina | -15 ukuya -20 °C |
| IKhowudi yoMrhumo eHarmonized | 29349990 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omhlophe |
| Isivavanyi | >99% |
| Amanzi | <10% |
I-RasGrf1 kunye ne-RasGrf2 yimiba yokutshintshiselana nge-mammalian guanine nucleotide ekwaziyo ukwenza i-Ras okanye i-Rho GTPase ethile isebenze.Iijini ze-RasGrf zikhethwa ngokukhethekileyo kwinkqubo ye-nervous ephakathi, nangona ukubonakaliswa okuthe ngqo kwe-locus kunokuthi kwenzeke kwenye indawo.I-RasGrf1 yimfuza echazwa nguyise, eshicilelwe kuphela emva kokuzalwa.Ngokwahlukileyo, iRasGrf2 ayishicilelwanga kwaye ibonisa ipateni ebanzi yokubonakalisa.Iindidi ze-isoform zazo zombini iijini zikwabonakala kwiimeko ezahlukeneyo zeselula.Iiprotheyini ze-RasGrf zibonisa izakhiwo zemodyuli eziqulunqwe ngamacandelo amaninzi aquka i-CDC25H kunye ne-DHPH motifs enoxanduva lokukhuthaza utshintshiselwano lwe-GDP / GTP, ngokulandelanayo, kwiithagethi ze-Ras okanye i-Rho GTPase.Imimandla eyahlukeneyo ibalulekile ekuchazeni umsebenzi wabo wangaphakathi wokutshintshiselana kunye nokumodareyitha okucacileyo komsebenzi wabo osebenzayo ukuze badibanise iisignali ezahlukeneyo ezinyukayo kwiithagethi ezahlukeneyo zomlambo kunye neempendulo zeselula.Ngaphandle kwe-homology yazo, i-RasGrf1 kunye ne-RasGrf2 zibonisa izinto ekujoliswe kuzo ezahlukeneyo kunye neendima ezisebenzayo ezingadibaniyo kwiindidi zemixholo yomqondiso enxulumene nokukhula kweeseli kunye nokwahlula kunye nokuchulumancisa kwe-neuronal kunye nokuphendula okanye i-synaptic plasticity.Nangona zombini ii-RasGrfs zisebenza nge-glutamate receptors, i-G-protein-coupled receptors okanye utshintsho kwi-intracellular calcium concentration, i-RasGrf1 kuphela ixelwe ukuba isebenze yi-LPA, i-cAMP, okanye i-agonist-activated Trk kunye ne-cannabinoid receptors.Uhlalutyo lweentlobo ezahlukeneyo zeegundane zokunkqonkqoza luye lwafumanisa igalelo elithile elisebenzayo le-RasGrf1 kwiinkqubo zememori nokufunda, i-photoreception, ulawulo lokukhula emva kokuzalwa kunye nobukhulu bomzimba kunye nomsebenzi we-pancreatic β-cell kunye ne-glucose homeostasis.Kwi-RasGrf2, iindima ezithile ekwandeni kwe-lymphocyte, iimpendulo ze-T-cell signaling kunye ne-lymphomagenesis zichazwe.
