Iimveliso

I-Guanosine analogues ezininzi, okt i-acyclovir (kunye neprodrug yomlomo ivalaciclovir), i-penciclovir (kwimo yeprodrug yomlomo, i-famciclovir) kunye ne-ganciclovir, zisetyenziswa ngokubanzi kunyango lwe-herpesvirus [okt i-herpes simplex virus type 1 (HSV-1), kunye nohlobo I-2 (HSV-2), i-varicella-zoster virus (VZV) kunye / okanye i-cytomegalovirus yabantu (HCMV)] usulelo.Kwiminyaka yakutshanje, ii-analogues ezininzi ze-guanosine ziye zaphuhliswa, kubandakanywa i-3-membered cyclopropylmethyl kunye ne-methenyl derivatives (A-5021 kunye ne-synguanol) kunye ne-6-membered D- kunye ne-L-cyclohexenyl derivatives.Umsebenzi we-acyclic/carbocyclic guanosine analogues umiselwe ngokuchasene noluhlu olubanzi lweentsholongwane, kubandakanywa iHSV-1, HSV-2, VZV, HCMV, kunye ne-herpesviruses yabantu uhlobo 6 (HHV-6), uhlobo 7 (HHV- 7) kunye nohlobo lwe-8 (HHV-8), kunye ne-virus ye-hepatitis B (HBV).I-analogues entsha ye-guanosine (okt i-A-5021 kunye ne-D- kunye ne-L-cyclohexenyl G) zifunyenwe zisebenza ngokukodwa kwezo ntsholongwane (HSV-1, HSV-2, VZV) ezifakela i-thymidine kinase (TK), icebisa ukuba umsebenzi wabo we-antiviral (ubuncinci ngokuyinxenye) kuxhomekeke kwi-phosphorylation yi-TK eyenziwa yintsholongwane.Umsebenzi we-antiviral ophawulweyo waphawulwa nge-A-5021 ngokuchasene ne-HHV-6 kunye ne-D- kunye ne-L-cyclohexenyl G ngokuchasene ne-HCMV kunye ne-HBV.Umsebenzi we-antiviral we-acyclic / carbocyclic nucleoside analogues unokubonakaliswa ngokuphawulekayo yi-mycophenolic acid, inhibitor enamandla ye-inosine 5'-monophosphate (IMP) dehydrogenase.I-carbocyclic guanosine analogues entsha (oko kukuthi i-A-5021 kunye ne-D- kunye ne-L-cyclohexenyl G) ibambe isithembiso esikhulu, kungekhona nje njengee-antiviral agents kunyango lwe-herpesvirus usulelo, kodwa kunye ne-antitumor agents kunyango oludibeneyo lwejene / ichemotherapy yomhlaza, ngaphandle kokuba (inxalenye) iiseli ithumba ziye zadluliselwa yintsholongwane (HSV-1, VZV) TK gene.