I-IBMX, i-3-isobutyl-1-methylxanthine CAS: 28822-58-4 99%
| Inombolo Yekhathalogu | XD90566 |
| Igama lemveliso | I-IBMX, i-3-isobutyl-1-methylxanthine |
| CAS | 28822-58-4 |
| Ifomula yeemolekyuli | I-C10H14N4O2 |
| Ubunzima beMolekyuli | 222.244 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 2942000000 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo wekristale omhlophe ukuya kwengwevu |
| Isivavanyi | 99% |
I-BBS4 yenye yeeproteni ezininzi ezineziphene ezibangela i-Bardet-Biedl syndrome (BBS), i-multi-systemic disorder, ebonakala ngokutyeba okuphawulweyo.Iipolymorphisms ze-BBS4 ziye zanxulunyaniswa nokutyeba okuqhelekileyo okungeyo-syndromic.Iindlela ze-BBS4 zokutyeba kakhulu zemolekyuli, kunye nendima ye-BBS4 yofuzo kulwahlulo lwe-adipocyte kunye nomsebenzi awaziwa ngokupheleleyo.Ngoku sibonisa ukuba i-Bbs4 idlala indima ethe ngqo kunye nebalulekileyo ekwandeni kunye ne-adipogenesis: ukuthuliswa kwe-Bbs4 kwi-3T3F442A i-preadipocytes eyenza ukuhlukana kweeseli okukhawulezileyo kunye nokwahlukana okungahambi kakuhle, okubonakalayo ngezifundo ze-morphologic (ukukhanya, ukuskena kunye nokuhanjiswa kwe-electron microscopy), uhlalutyo lwe-metabolic iprofayili ye-fatty acid kunye ne-lipolysis) kunye ne-adipogenic markers transcripts (Cebpα, Pparγ, aP2, ADRP, Perilipin).Kuyo yonke i-adipogenesis kwaye xa ucelomngeni ngomthwalo wamafutha, iiseli ze-Bbs4 ezithulisiwe ziqokelela kakhulu i-triglycerides ngaphezu kokulawula i-adipocytes, nangona kuncinci (kodwa kuninzi kwinani) amaconsi aqukethe iiprofayili ze-fatty acid modified.Ke, ukuqokelelwa kwamafutha amakhulu kwiiseli ezithulisiweyo sisiphumo senqanaba eliphezulu lokunyuka kwe-adipocyte kunye nokwahlulahlula okugwenxa okukhokelela ekuqokeleleni okungaqhelekanga kwamafutha kwiseli nganye.Iziphumo zethu zibonisa ukuba ukutyeba kwe-BBS kusenokuba ngenxa yendima ethe ngqo ye-BBS4 kwiinkqubo ze-physiological and pathophysiological ezibeka ukwakheka kwezicubu ze-adipose ezihambelana nokutyeba.
