Iimveliso

I-7-Hydroxygranisetron yikhompawundi esebenza njengeyeza kwintsimi yeyeza.Kukwiklasi yeziyobisi eyaziwa ngokuba yi-serotonin ekhethiweyo ye-5-HT3 yabachasi be-receptor.Le khompawundi yi-metabolite ye-granisetron, ichiza elisetyenziswa ngokuqhelekileyo le-antiemetic.Injongo ephambili ye-7-Hydroxygranisetron kukuthintela nokunyanga isicaphucaphu kunye nokuhlanza, ngakumbi ezo zihambelana ne-chemotherapy okanye iinkqubo zotyando.I-Chemotherapy-induced nausea and vomiting (CINV) yinkxalabo ebalulekileyo kwizigulane zomhlaza ezifumana unyango.Ezi ziphumo bezingalindelekanga zinokuchaphazela kakubi umgangatho wobomi besigulane kwaye zinokukhokelela kuphazamiseko lonyango.I-7-Hydroxygranisetron isebenza ngokuthintela i-serotonin receptors ezithile kwinkqubo ye-nervous central, ngokukodwa ezo zikwindawo ye-chemoreceptor trigger zone kunye neziko lokuhlanza.Ngokwenza njalo, kunceda ukunciphisa iimpawu ezibangela isicathulo kunye nokuhlanza, ukubonelela ngokukhululeka kwizigulane.Ngaphezu kokusetyenziswa kwayo kwi-CINV, i-7-Hydroxygranisetron nayo ibonise isithembiso ekulawuleni isicaphucaphu emva kokusebenza kunye nokuhlanza (PONV).Emva kweenkqubo zotyando, izigulana zidla ngokufumana isicaphucaphu kunye nokuhlanza ngenxa yemiphumo ye-anesthesia kunye nezinye izinto.I-7-Hydroxygranisetron inceda ukukhusela nokulawula ezi zimpawu, zivumela izigulane ukuba zibuyele ngokukhululekileyo.Xa ilawulwa, i-7-Hydroxygranisetron inikezelwa ngokuqhelekileyo nge-intravenously okanye ngomlomo, kuxhomekeke kwimeko yesigulane kunye neemfuno zonyango.Idosi inokwahluka ngokusekelwe kwizinto ezifana nobunzima bomntu, inkqubo ethile okanye unyango, kunye nobukhulu beempawu.Kubalulekile ukulandela idosi emiselweyo kunye nemiyalelo enikezelwa ngabasebenzi bezempilo ukuqinisekisa ukusebenza kakuhle kunye nokuphepha nayiphi na imiphumo enokubakho.Njengamayeza amaninzi, i-7-Hydroxygranisetron ingaba nemiphumo enokubakho.Oku kunokubandakanya intloko ebuhlungu, ukuqhinwa, urhudo, isiyezi, nokudinwa.Kwiimeko ezinqabileyo, abantu ngabanye banokufumana ukungahambisani nomzimba okanye iziphumo ezibi kakhulu.Kubalulekile ukubika nayiphi na into ephathelele iimpawu okanye ukusabela kumboneleli wezempilo ukuze kuphononongwe kunye nolawulo olufanelekileyo.Ekuqukunjelweni, i-7-Hydroxygranisetron iyeza elisetyenziswa ngokuyinhloko ukukhusela nokuphatha isicaphucaphu kunye nokuhlanza okuhambelana ne-chemotherapy kunye neenkqubo zotyando.Ngokuthintela i-serotonin receptors ezithile kwinkqubo ye-nervous central, inceda ukunciphisa ezi mpawu zicinezelayo kwizigulana ezinomhlaza kunye nabantu abachacha kuqhaqho.Nangona kunjalo, njengawo nawaphi na amayeza, wona