Iodonitrotetrazolium chloride CAS: 146-68-9
| Inombolo Yekhathalogu | XD90473 |
| Igama lemveliso | Iodonitrotetrazolium chloride |
| CAS | 146-68-9 |
| Ifomula yeemolekyuli | I-C19H13ClIN5O2 |
| Ubunzima beMolekyuli | 505.70 |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 32129000 |
Ukucaciswa kweMveliso
| Ukuchongwa | H-NMR |
| Imbonakalo | Umthubi okhanyayo ukuya kumgubo o-orenji |
| Isivavanyi | >99% |
| Ukunyibilika | Isisombululo esicacileyo |
I-Interferon-induced transmembrane protein 1 (IFITM1) yenye ye-interferon-induced transmembrane amalungu entsapho.Kulo pho nonongo, sixele ukuba i-IFITM1 ephakamileyo ibonakaliso kumdlavuza we-colorectal wabantu (CRC) ihambelana kakhulu ne-CRC lymph node kunye ne-metastasis yomgama kunye nenqanaba eliphezulu leklinikhi.Okubalulekileyo, inkcazo ye-IFITM1 ephakamileyo yinto ezimeleyo yeprognostic factor yokuphila kakubi.Ukuphanda iindlela ze-molecular, sibonise ukuba ukugqithisa kwe-IFITM1 kwiiseli ze-CRC ezikhuthazwayo, ngelixa i-knockdown ye-IFITM1 ibonakaliso inqatshelwe, ukufuduka kweeseli / ukuhlasela kunye ne-tumorigenicity in vitro.Ngaphezu koko, sichonge i-Caveolin-1 (CAV1) njengento ekujoliswe kuyo ezantsi kwe-IFITM1-induced cell invasion, njenge-knockdown ye-CAV1 echithiweyo ye-siIFITM1 yokuthintela ukuhlaselwa kweeseli kwiiseli ze-CRC.Ukongezelela, kwiqela le-CRC lezigulane ze-229, inkcazo ye-IFITM1 ihambelana ngokungafaniyo kunye nenkcazo ye-CAV1.Ezi ziphumo zicebise ukuba i-IFITM1 ikhuthaza i-aggr essiveness yeeseli ze-CRC, kwaye yinto enokubakho i-prognostic marker kunye nethagethi yonyango ye-CRC.
