I-L-Histidine Cas: 71-00-1 98.5% Iikristale ezimhlophe okanye i-crystalline powder
| Inombolo Yekhathalogu | XD90301 |
| Igama lemveliso | L-Histidine |
| CAS | 71-00-1 |
| Ifomula yeemolekyuli | C6H9N3O2 |
| Ubunzima beMolekyuli | 155.15 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 29332990 |
Ukucaciswa kweMveliso
| Isivavanyi | 98.5% min |
| Imbonakalo | Iikristale ezimhlophe okanye i-crystalline powder |
| IBanga | USP39 |
| Ukujikeleza okuthe ngqo | +12,6 ° ukuya +14.0 ° |
| Ukuchongwa | Ukufunxwa kwe-infrared |
| pH | 7.0 - 8.5 |
| SO4 | <=0.03% |
| Fe | <=30ppm |
| Ilahleko ekomisweni | <=0.2% |
| Intsalela kwi-Ignition | <=0.1% |
| Cl | <=0.05% |
| Iintsimbi ezinzima ( PB ) | <=15ppm |
| Amachiza anxulumeneyo | Akukho ngaphezulu kwe-0.5% yakho nakuphi na ukungcola komntu okufunyenweyo;Akukho ngaphezu kwe-2.0% yokungcola okupheleleyo kufunyenwe |
i-quadruplex eyenza ulandelelwano lwe-G-rich asasazwa ngokulinganayo kuyo yonke igenome yomntu.Ukutyetyiswa kwabo kubakhuthazi be-oncogenic kunye ne-telomeres baye bavelisa umdla ekujoliseni i-G-quadruplex (GQ) yonyango lwe-anticancer.Apha, sibonisa uhlalutyo lobungakanani malunga nokuhambelana kunye ne-dynamics ye-GQ yokwenza ulandelelwano olulinganiswe nge-molecule ye-fluorescence enye.Ukongezelela, sinxulumanisa ezi zakhiwo kunye ne-GQ ejolise kwi-ligands kunye ne-G4 resolvase 1 (G4R1) i-protein binding.Isiphumo sethu sibonisa ukuba zombini i-loop (i-non-G components) ubude kunye nolandelelwano negalelo ekuqulunqweni kwe-GQ.Ixesha lokwenyani umkhondo wemolekyuli enye ityhila ukuba amandla okusonga nawo axhomekeke kulwakhiwo lwelophu.Sibonisa ukuba i-GQ-izinzisa iimolekyuli ezincinci, i-N-methyl mesoporphyrin IX (NMM), i-analog yayo, i-NMP kunye ne-G4R1 iprotheni ibophelela ngokukhethiweyo kwi-conformation ye-GQ efanayo.Iziphumo zethu zikhomba ubunzima bokugoba kwe-GQ elawulwa bubude be-loop kunye nokulandelelana kunye nendlela i-GQ conformation inquma ngayo i-molecule encinci kunye neprotheyini yokubopha i-propensity.
