I-L-Hydroxyproline Cas: 51-35-4 powder omhlophe
| Inombolo Yekhathalogu | XD90292 |
| Igama lemveliso | I-L-Hydroxyproline |
| CAS | 51-35-4 |
| Ifomula yeemolekyuli | C5H9NO3 |
| Ubunzima beMolekyuli | 131.13 |
| Iinkcukacha zokuGcina | I-Ambient |
| IKhowudi yoMrhumo eHarmonized | 2933998040 |
Ukucaciswa kweMveliso
| Isivavanyi | 99% |
| Imbonakalo | Umgubo omhlophe |
I-Idiopathic pulmonary fibrosis kucingelwa ukuba ibandakanya ukulimala kwemiphunga okubangelwa zintlobo ze-oksijini esebenzayo (ROS), elandelwa yi-fibrosis engaqhelekanga.Ukutshintsha kwemeko yokukhula (TGF) -β1-inyuswe kwinani le-myofibroblast idlala indima ebalulekileyo kule fibrosis engaqhelekanga.Kutshanje siye safumanisa ukuba i-mepenzolate bromide (i-mepenzolate), esetyenziswe kwiklinikhi ukunyanga ukuphazamiseka kwesisu, ineempawu zokunciphisa i-ROS.Kuphononongo lwangoku, sivavanye isiphumo se-mepenzolate kwi-bleomycin-induced pulmonary fibrosis kunye nokungasebenzi kakuhle kwemiphunga kwiimpuku.Ubunzima be-pulmonary fibrosis buhlolwe ngovavanyo lwe-histopathologic kunye nokuzimisela kwamanqanaba e-hydroxyproline.I-Lung mechanics (i-elastance) kunye nomsebenzi wokuphefumla [umthamo obalulekileyo wokunyanzeliswa (FVC)] zavavanywa kusetyenziswa i-ventilator elawulwa yikhompyutha.Umsebenzi wokuphefumula uphinde wavavanywa ngokubeka iliso kwi-percutaneous arterial saturation (SpO2).Ulawulo lwe-intracheal ye-mepenzolate ngaphambi konyango lwe-bleomycin lunciphise ubungakanani be-pulmonary fibrosis kunye notshintsho kwi-lung mechanics kwaye kukhokelele ekubuyiseleni okubonakalayo kuzo zombini i-FVC kunye ne-SpO2 xa kuthelekiswa nolawulo.Ngaphaya koko, i-mepenzolate yavelisa isiphumo sonyango nangona yayilawulwa emva kophuhliso lwe-fibrosis.Ulawulo lwe-mepenzolate lukwathintele ukufa kweeseli ze-bleomycin-induced pulmonary cell kunye neempendulo ezivuthayo kunye nokwanda kwenani le-myofibroblast.I-Mepenzolate iphinde yehlise umsebenzi we-NADPH oxidase kunye nenqanaba elisebenzayo le-TGF-β1 okanye ukunyuka kwe-glutathione S-transferase (GST) umsebenzi phambi konyango lwe-bleomycin.Ezi ziphumo zibonisa ukuba ukulawulwa kwe-intracheal ye-mepenzolate kunciphise i-bleomycin-induced pulmonary fibrosis kunye nokungasebenzi kakuhle kwemiphunga kwiimpuku.Ezi ziphumo zinokuthi zibangelwa yimpembelelo ye-inhibitory yeli chiza kwi-NADPH oxidase kunye nemisebenzi ye-TGF-β1 kunye nefuthe layo elikhuthazayo kwi-GST.
