Ukukhanya okuluhlaza SF Cas: 5141-20-8 Umgubo omfusa onzulu
| Inombolo Yekhathalogu | XD90538 |
| Igama lemveliso | Ukukhanya okuluhlaza SF |
| CAS | 5141-20-8 |
| Ifomula yeemolekyuli | C₃₇H₃₄N₂Na₂O₉S₃ |
| Ubunzima beMolekyuli | 792.86 |
| Iinkcukacha zokuGcina | -15 ukuya -20 °C |
| IKhowudi yoMrhumo eHarmonized | 32129000 |
Ukucaciswa kweMveliso
| Imbonakalo | Umgubo omfusa onzulu |
| Isivavanyi | 99% |
| Ukunyibilika | I-Soluble emanzini ukunika isisombululo esicacileyo esiluhlaza |
Ukuvavanya ngokucwangcisiweyo iimpawu zokungcola kunye nokhuseleko lweedayi ezinokuthi zibekho zokuhlinzwa kwi-intraocular.Idayi ezintandathu zifakiwe kuphando: ukukhanya okuluhlaza SF (LGSF) yellowish, E68, bromophenol blue (BPB), Chicago blue (CB), rhodamine 6G, rhodulinblau -isiseko 3 (RDB-B3).Zonke iidayi zachithwa kwaye zixutywe kwisisombululo se-saline saline elinganayo.Iimpawu zokunciphisa ukukhanya kwedayi nganye zilinganiswe kwi-concentration ye-0.05% phakathi kwe-200 kunye ne-1000 nm.Iimpawu ze-staining zihlolwe ngokungcolisa i-lens capsule tissue kunye ne-epiretinal membranes (ERMs), zisuswe nge-intraoperative, kunye noxinzelelo lwedayi ye-1.0%, 0.5%, 0.2%, kunye ne-0.05%.Amehlo e-enucleated porcine (ixesha le-postmortem, iiyure ze-9) nazo zazichanekile.Ityhefu enxulumene nedayi yavavanywa ngovavanyo lwe-colorimetric (MTT) ukulinganisa inhibition ye-retinal pigment epithelium (RPE) ukwanda kweeseli (ARPE-19 kunye neeseli eziphambili ze-RPE zabantu, iipaseji ze-3-6).Ukusebenza kweeseli nako kulinganiswe ngokusekwe kuvavanyo lokusebenza kweseli olunemibala emibini.Iidayi zaphandwa kwi-concentration ye-0.2% kunye ne-0.02%.Zonke iidayi eziphandwayo kolu cwaningo zingcolise ii-capsules ze-lens zabantu, zisuswe ngaphandle kokusebenza;ii-ERM, ezixotshiweyo ngexesha lotyando lwe-macular pucker;kunye ne-enucleated porcine amehlo, kuxhomekeke kugxininiso olusetyenzisiweyo.Ubuninzi be-long-wavelength absorption yedayi yayingaphakathi koluhlu lwe-527 ukuya kwi-655 nm ekugxininiseni kwe-0.05%.I-Rhodamine G6 kunye ne-RDB-B3 ibonise imiphumo emibi kwi-ARPE-19 ukwanda kweeseli kwi-concentration ye-0.2% kwaye yayingabandakanywa kuphando olongezelelweyo kwiiseli eziphambili ze-RPE.Iidayi ezine ezisele azibonisi umphumo wetyhefu kwi-ARPE-19 kunye ne-primary RPE cell proliferation kwi-concentrations ye-0.2% kunye ne-0.02%.Ukusebenza kweeseli kuchatshazelwa yi-LGSF emthubi (0.2%) kunye ne-CB (0.2% kunye ne-0.02%).Iidayi ezimbini (E68 kunye ne-BPB) azibonakalisi ubutyhefu obufanelekileyo kwi-vitro.Uvavanyo olucwangcisiweyo lweedayi zokusetyenziswa kwe-intraocular lubonakala lunyanzelekile.Kolu phononongo iidayi ezine zichongiwe ezineempawu ezisebenzayo zokuthambisa, ezimbini kwezi dayi zingenayo isiphumo esibonakalayo esiyityhefu kwiiseli zeRPE kwi-vitro.
