Iimveliso

ILinagliptin Intermediate F, ekwaziwa ngokuba yi-3-aminopiperidine-1-carboxylic acid, iyikhompawundi ebalulekileyo yeekhemikhali ekudibaneni kwe-linagliptin, iyeza elisetyenziselwa ukunyanga isifo seswekile esi-2.ILinagliptin iyinxalenye yamayeza aziwa ngokuba zii-dipeptidyl peptidase-4 (DPP-4) inhibitors, anceda ekulawuleni amanqanaba eswekile yegazi.Isebenza njengebhloko yokwakha ephambili ukwenza isakhelo sekhemikhali esisodwa se-linagliptin ngokwenza uthotho lweempendulo.Esi siphakathi sisetyenziswa ngokukodwa ekudityanisweni kweringi engundoqo yepiperidine yesakhiwo semolekyuli yelinagliptin.Yakuba idityanisiwe, i-linagliptin isebenza ngokuthintela umsebenzi we-enzymatic we-DPP-4.I-DPP-4 inhibitors isebenza ngokuthintela ukuwohloka kwamahomoni e-incretin, afana ne-glucagon-like peptide-1 (GLP-1), enoxanduva lokukhuthaza ukukhutshwa kwe-insulin kunye nokucinezela ukukhutshwa kweglucagon.Ngokuthintela i-DPP-4, i-linagliptin yandisa ixesha le-hormone ye-incretin, ekhokelela ekuphuculeni ukulawulwa kweswekile yegazi kubantu abanesifo sikashukela sohlobo lwe-2. I-Linagliptin ichazwe ngokuqhelekileyo njengento edibeneyo yokutya kunye nokuzivocavoca ekulawuleni uhlobo lwe-2 yeswekile.Iyaziwa ngesiqingatha sobomi bayo obude, obuvumela ukuba kube lula ukudosa kube kanye ngemini.I-Linagliptin ibonakaliswe ukuba inciphisa ngokufanelekileyo i-hemoglobin A1c, uphawu lokulawula i-glucose yexesha elide, kwaye ixhatshazwa kakuhle zizigulane. Oku kunokuchaphazela kakhulu ubomi babantu abanesifo seswekile se-2.Ngokufaka isandla ekudalweni kwesakhiwo sekhemikhali esiyingqayizivele se-linagliptin, le nxalenye ephakathi yenza ukuba umkhiqizo wokugqibela uthintele ngokufanelekileyo i-DPP-4 kwaye uphucule ukulawulwa kwe-glycemic.Ekuqukumbeleni, i-Linagliptin Intermediate F yinto ebalulekileyo yeekhemikhali kwi-synthesis ye-linagliptin, i-DPP-4 inhibitor. isetyenziselwa unyango lwesifo sikashukela sohlobo lwe-2.Indima yayo ekudaleni i-linagliptin ye-molecular structure igxininisa ukubaluleka kwayo ekuveliseni iyeza elinokuphucula ulawulo lweswekile yegazi kunye nokuphucula ulawulo lwesifo seswekile.Ngokuthintela i-DPP-4, i-linagliptin inceda ukulawula amanqanaba eswekile yegazi kwaye inegalelo kwimpilontle ngokubanzi yabantu abanesifo seswekile esi-2.