I-Lipase esuka kwi-pancreas ye-porcine CAS: 9001-62-1 Brown ukuya kwi-beige powder
| Inombolo Yekhathalogu | XD90387 |
| Igama lemveliso | I-Lipase evela kwi-pancreas ye-porcine |
| CAS | 9001-62-1 |
| Ifomula yeemolekyuli | N / A |
| Ubunzima beMolekyuli | N / A |
| Iinkcukacha zokuGcina | 2 ukuya ku-8 °C |
| IKhowudi yoMrhumo eHarmonized | 35079090 |
Ukucaciswa kweMveliso
| Uthuthu | <12% |
| AS | <2mg/kg |
| Pb | <2mg/kg |
| Umxholo wamanzi | <8% |
| Isivavanyi | 99% |
| Umsebenzi we-Enzyme | >30000u/g |
| Imbonakalo | I-Brown ukuya kwi-beige powder |
| Iqela leColiform | <30MPH/100g |
| Isetyenziselwa uphando kuphela, hayi ukusetyenziswa komntu | uphando lusetyenziselwa kuphela, kungekhona ukusetyenziswa komntu |
Ukuguqulwa kwe-triglyceride (TG) ye-metabolism kwiiseli ze-vascular smooth muscle (SMC) zinokuthi zihambelane ne-phenotype ethile, nangona oku akuzange kucaciswe.I-Adipose triglyceride lipase (ATGL) yenza umsebenzi omkhulu we-TG we-catalytic kuzo zombini iiseli ze-adipotic kunye ne-non-adipotic.Kuphononongo lwangoku, sahlukanisa i-SMC kwi-ATGL-intsilelo iigundane (ATGL (-/-) mSMC).I-ATGL (-/-) mSMC ibonise ukuqokelela kwe-TG okuzenzekelayo kunye nempendulo ye-mitogenic ephantsi kunye nokubonakaliswa kwe-muscle actin (SMA) xa kuthelekiswa ne-ATGL (+/+) mSMC.Ipesenti ye-senescence enxulumene ne-_-galactosidase iiseli ezilungileyo zonyuswe kwi-ATGL (-/-) mSMC.I-PCR yexesha langempela ilandelwa kukuhlolwa kunye nohlalutyo olugxininisiweyo lwe-DNA lubonakalise ukubonakaliswa kwe-glucokinase (i-1.7-fold), i-lipoprotein lipase (i-3.8-fold) kunye ne-interleukin-6 (i-3.7-fold) kunye nenkcazo ephantsi yokulawulwa kokukhula kwe-vascular endothelial. factor-A (0.2-fold), uhlobo I collagen (0.5-fold), kunye nokuguqula ukukhula factor-_ (0.4-fold) kwi ATGL (-/-) mSMC xa kuthelekiswa ATGL (+/+) mSMC.Emva koko, i-ectopic gene transfer ye-ATGL yomntu yazama ukusebenzisa i-doxycycline (Dox) -elawulayo i-myc-DDK-tagged adenovirus vector (AdvATGL).Ukusuleleka kwe-AdvATGL kubangele ukunciphisa ukuqokelela kwe-TG kunye nempendulo ye-mitogenic ephakamileyo kunye nokubonakaliswa kwe-SMA, kwaye yehla kwiinombolo zeseli ze-senescent kwi-ATGL (-/-) mSMC.Ngaphezu koko, ipateni yegene etenxileyo yokubonisa kwi-ATGL(-/-)mSMC inokubanakho ukulungiswa.Idatha yethu ibonisa ukuba i-ATGL (-/-) mSMC ine-phenotype eyahlukileyo enokuthi ihambelane ne-vascular pathogenesis.Iplastiki ye-phenotypes ye-SMC ehambelana ne-lipid metabolism ingaba yinto ekujoliswe kuyo yonyango.
